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2024, Vol: 14, Issue: 4
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Research Article 


In Vitro Activities of Ceftazidime-avibactam and Comparator Antimicrobial Agents Tested against ESBL Producing Urinary E. coli Isolates

Estelle Caine, Ozlem Koyuncu Ozyurt, Gozde Ongut, Kubra Kasaroglu, Emre Yıldız, Dilara Ogunc, Filiz Gunseren, Dilek Colak, Ozge Turhan, Betil Ozhak.


Cited By:3

Abstract
Objectives: Urinary tract infections (UTIs) remain one of the most common infections for antibiotic prescription. Increased resistance to antibiotics currently used to treat these infections may lead to significant problems. Extended spectrum beta-lactamase (ESBL) production in organisms causing UTIs are often responsible for the increase in resistance. The aim of this study was to investigate the in vitro antimicrobial susceptibility of ESBL producing community acquired urinary E. coli isolates to Ceftazidime/Avibactam (CAZ/AVI) and other antimicrobial agents using disk diffusion method.
Methods: Between 2016 and 2017, a total of 100 ESBL producing E. coli urine isolates were collected from outpatients who had no history of hospitalization in the last three months in Akdeniz University Hospital. All isolates were tested for in vitro susceptibility to the CAZ/AVI and other antimicrobial agents using disk diffusion method. Results: No CAZ/AVI and carbapenem resistance were observed. Resistance rates to other antimicrobial agents were as follows: ampicillin 100%, amoxicillin/clavulanate 85%, cefotaxime 98%, ceftazidime 89%, cefepime 82%, gentamicin 41%, ciprofloxacin 65%, levofloxacin 39%, fosfomycin 3%, nitrofurantoin 2%, trimethoprim/sulfamethoxazole 72% and Piperacillin/Tazobactam 41%.
Conclusions: Our results showed that ceftazidime / avibactam, carbapenems, nitrofurantoin and fosfomycin may be among the first line treatment options in the empirical therapy. In selected patients, CAZ/AVI could be an option for the treatment of UTI caused by ESBL producing E.coli which may reduce the use of carbapenems. J Microbiol Infect Dis 2019; 9(2):112-115.


 
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How to Cite this Article
Pubmed Style

Caine E, Ozyurt OK, Ongut G, Kasaroglu K, Yıldız E, Ogunc D, Gunseren F, Colak D, Turhan O, Ozhak B. In Vitro Activities of Ceftazidime-avibactam and Comparator Antimicrobial Agents Tested against ESBL Producing Urinary E. coli Isolates. J Microbiol Infect Dis. 2019; 9(3): 112-115 . doi:10.5799/jmid.614195

Web Style

Caine E, Ozyurt OK, Ongut G, Kasaroglu K, Yıldız E, Ogunc D, Gunseren F, Colak D, Turhan O, Ozhak B. In Vitro Activities of Ceftazidime-avibactam and Comparator Antimicrobial Agents Tested against ESBL Producing Urinary E. coli Isolates. https://www.jmidonline.org/?mno=302657025 [Access: January 09, 2025]. doi:10.5799/jmid.614195

AMA (American Medical Association) Style

Caine E, Ozyurt OK, Ongut G, Kasaroglu K, Yıldız E, Ogunc D, Gunseren F, Colak D, Turhan O, Ozhak B. In Vitro Activities of Ceftazidime-avibactam and Comparator Antimicrobial Agents Tested against ESBL Producing Urinary E. coli Isolates. J Microbiol Infect Dis. 2019; 9(3): 112-115 . doi:10.5799/jmid.614195


Vancouver/ICMJE Style

Caine E, Ozyurt OK, Ongut G, Kasaroglu K, Yıldız E, Ogunc D, Gunseren F, Colak D, Turhan O, Ozhak B. In Vitro Activities of Ceftazidime-avibactam and Comparator Antimicrobial Agents Tested against ESBL Producing Urinary E. coli Isolates. J Microbiol Infect Dis. (2019), [cited January 09, 2025]; 9(3): 112-115 . doi:10.5799/jmid.614195


Harvard Style

Caine, E., Ozyurt, . O. K., Ongut, . G., Kasaroglu, . K., Yıldız, . E., Ogunc, . D., Gunseren, . F., Colak, . D., Turhan, . O. & Ozhak, . B. (2019) In Vitro Activities of Ceftazidime-avibactam and Comparator Antimicrobial Agents Tested against ESBL Producing Urinary E. coli Isolates. J Microbiol Infect Dis, 9 (3), 112-115 . doi:10.5799/jmid.614195


Turabian Style

Caine, Estelle, Ozlem Koyuncu Ozyurt, Gozde Ongut, Kubra Kasaroglu, Emre Yıldız, Dilara Ogunc, Filiz Gunseren, Dilek Colak, Ozge Turhan, and Betil Ozhak. 2019. In Vitro Activities of Ceftazidime-avibactam and Comparator Antimicrobial Agents Tested against ESBL Producing Urinary E. coli Isolates. Journal of Microbiology and Infectious Diseases, 9 (3), 112-115 . doi:10.5799/jmid.614195


Chicago Style

Caine, Estelle, Ozlem Koyuncu Ozyurt, Gozde Ongut, Kubra Kasaroglu, Emre Yıldız, Dilara Ogunc, Filiz Gunseren, Dilek Colak, Ozge Turhan, and Betil Ozhak. "In Vitro Activities of Ceftazidime-avibactam and Comparator Antimicrobial Agents Tested against ESBL Producing Urinary E. coli Isolates." Journal of Microbiology and Infectious Diseases 9 (2019), 112-115 . doi:10.5799/jmid.614195


MLA (The Modern Language Association) Style

Caine, Estelle, Ozlem Koyuncu Ozyurt, Gozde Ongut, Kubra Kasaroglu, Emre Yıldız, Dilara Ogunc, Filiz Gunseren, Dilek Colak, Ozge Turhan, and Betil Ozhak. "In Vitro Activities of Ceftazidime-avibactam and Comparator Antimicrobial Agents Tested against ESBL Producing Urinary E. coli Isolates." Journal of Microbiology and Infectious Diseases 9.3 (2019), 112-115 . Print. doi:10.5799/jmid.614195


APA (American Psychological Association) Style

Caine, E., Ozyurt, . O. K., Ongut, . G., Kasaroglu, . K., Yıldız, . E., Ogunc, . D., Gunseren, . F., Colak, . D., Turhan, . O. & Ozhak, . B. (2019) In Vitro Activities of Ceftazidime-avibactam and Comparator Antimicrobial Agents Tested against ESBL Producing Urinary E. coli Isolates. Journal of Microbiology and Infectious Diseases, 9 (3), 112-115 . doi:10.5799/jmid.614195


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