Abstract
Purpose: Antibiotics are drugs used to treat and prevent bacterial infections. The emergence of antibiotic resistance in bacterial strains is one of the most important problems facing global health care. There are several alternatives to get rid of antibiotic resistance, including nanoparticles, which is the subject of this study on how to use Manganese nanoparticles (MnNPs) as antimicrobials with greater effectiveness and less resistance to them.
Materials and Methods: There are several physical, chemical, and biological techniques for the production of nanoparticles. But the Green synthesis of nanoparticles has been developed to improve the environment and human health safety, minimize pollution, and save expenses by using plant extracts instead of industrial chemical components to reduce metal ions. Biological activity, safety, and reproducibility in the production of these MnNPs depend on accurate and comprehensive characterization by using many physicochemical techniques.
Results: Green synthesized of MnNPs are a promising source of new antiviral, antibacterial and antifungal agents considering the multiplicity of its mechanism and the multiple target areas in the microbs. The MnNPs interact directly with some biological molecules of the microbs, such as some proteins, DNA, and RNA.This reaction generates Reactive Oxygen Species (ROS), causing damage to the membranes in the microbes. Metal nano-therapies such as MnNPs are granted research consideration for virus, bacteria or fungi treatment.
Conclusion: The biocompatibility achieved through green synthesis of MnNPs suggests its possible use in several types of microbe’s infections with less risk of toxicity of these new materials.

Key words: MnO NPs, Green synthesis, Nanobiotechnology, Microbial infections, Antibiotic resistance