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2024, Vol: 14, Issue: 4
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Case Report 


Disseminated Histoplasmosis Post-IL6 Inhibitor Use in A COVID-19 Patient

Brijesh Sharma, Premapassan Krishnamurthy, Desh Deepak, Shailja Shukla, Vishakha Arya, Anuradha Chowdhary.


Cited By:3

Abstract
We report a case of a 40-year-old male patient who developed a fever one week after recovering from severe COVID-19 illness that had needed treatment with injectable corticosteroids and Tocilizumab. The patient had had maculopapular lesions on his trunk months before contracting COVID-19, but the skin lesions progressed along with the post-covid fever. Detailed workup and biopsy from skin lesions on the face, trunk, and bone marrow revealed Histoplasmosis. This case highlights the possibility of flaring up of Histoplasmosis in COVID-19 patients who have been treated with immunosuppressants. In our case, the plausible reason for reactivation and growth of Histoplasma may be the suppression of IL6 action by Tocilizumab.
It may be prudent to screen patients for Histoplasma and other fungal infections like aspergillus before administering an immune-suppressive regimen in patients with a moderate or severe COVID-19 illness. Urinary Histoplasma antigen may be used for screening in these patients. J Microbiol Infect Dis 2021; 11(3):170-173.

Key words: COVID-19, IL6 inhibitor, Histoplasmosis


 
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How to Cite this Article
Pubmed Style

Sharma B, Krishnamurthy P, Deepak D, Shukla S, Arya V, Chowdhary A. Disseminated Histoplasmosis Post-IL6 Inhibitor Use in A COVID-19 Patient. J Microbiol Infect Dis. 2021; 11(3): 170-173 . doi:10.5799/jmid.994001

Web Style

Sharma B, Krishnamurthy P, Deepak D, Shukla S, Arya V, Chowdhary A. Disseminated Histoplasmosis Post-IL6 Inhibitor Use in A COVID-19 Patient. https://www.jmidonline.org/?mno=302657247 [Access: January 09, 2025]. doi:10.5799/jmid.994001

AMA (American Medical Association) Style

Sharma B, Krishnamurthy P, Deepak D, Shukla S, Arya V, Chowdhary A. Disseminated Histoplasmosis Post-IL6 Inhibitor Use in A COVID-19 Patient. J Microbiol Infect Dis. 2021; 11(3): 170-173 . doi:10.5799/jmid.994001


Vancouver/ICMJE Style

Sharma B, Krishnamurthy P, Deepak D, Shukla S, Arya V, Chowdhary A. Disseminated Histoplasmosis Post-IL6 Inhibitor Use in A COVID-19 Patient. J Microbiol Infect Dis. (2021), [cited January 09, 2025]; 11(3): 170-173 . doi:10.5799/jmid.994001


Harvard Style

Sharma, B., Krishnamurthy, . P., Deepak, . D., Shukla, . S., Arya, . V. & Chowdhary, . A. (2021) Disseminated Histoplasmosis Post-IL6 Inhibitor Use in A COVID-19 Patient. J Microbiol Infect Dis, 11 (3), 170-173 . doi:10.5799/jmid.994001


Turabian Style

Sharma, Brijesh, Premapassan Krishnamurthy, Desh Deepak, Shailja Shukla, Vishakha Arya, and Anuradha Chowdhary. 2021. Disseminated Histoplasmosis Post-IL6 Inhibitor Use in A COVID-19 Patient. Journal of Microbiology and Infectious Diseases, 11 (3), 170-173 . doi:10.5799/jmid.994001


Chicago Style

Sharma, Brijesh, Premapassan Krishnamurthy, Desh Deepak, Shailja Shukla, Vishakha Arya, and Anuradha Chowdhary. "Disseminated Histoplasmosis Post-IL6 Inhibitor Use in A COVID-19 Patient." Journal of Microbiology and Infectious Diseases 11 (2021), 170-173 . doi:10.5799/jmid.994001


MLA (The Modern Language Association) Style

Sharma, Brijesh, Premapassan Krishnamurthy, Desh Deepak, Shailja Shukla, Vishakha Arya, and Anuradha Chowdhary. "Disseminated Histoplasmosis Post-IL6 Inhibitor Use in A COVID-19 Patient." Journal of Microbiology and Infectious Diseases 11.3 (2021), 170-173 . Print. doi:10.5799/jmid.994001


APA (American Psychological Association) Style

Sharma, B., Krishnamurthy, . P., Deepak, . D., Shukla, . S., Arya, . V. & Chowdhary, . A. (2021) Disseminated Histoplasmosis Post-IL6 Inhibitor Use in A COVID-19 Patient. Journal of Microbiology and Infectious Diseases, 11 (3), 170-173 . doi:10.5799/jmid.994001


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