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Letter to the Editor 


Molecular Detection of Leptospira in Pediatric Aseptic Meningitis

Ahmed M. H. Mohamed, Sami E. A. Algam, Abdel Rahim M El Hussein, Isam M Elkhidir, Khalid A Enan.


Abstract
Leptospirosis is a zoonotic disease caused by pathogenic Leptospira bacterial species. It is tremendously neglected, and scarce epidemiological data is present worldwide. Aseptic meningitis is a rare secondary manifestation of Leptospira infection. Molecular detection of leptospira DNA in cerebrospinal fluid (CSF) samples of children younger than two years is could be considered for diagnosis of aseptic meningitis.
A total of 50 CSF samples suspected of aseptic meningitis were collected from pediatric patients (<2 years) presenting to Omdurman Teaching Hospital in Khartoum state, Sudan, between June and September 2018. PCR was used to investigate the presence of leptospira DNA in these samples.
Out of the 50 CSF samples in our study, two samples (4%) tested positive for Leptospira DNA using PCR. Leptospira is an overlooked cause of aseptic meningitis in children, and PCR can be used for its diagnosis. J Microbiol Infect Dis 2022; 12(1):35-37.

Key words: Leptospira, pediatric, aseptic meningitis, diagnosis, molecular


 
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How to Cite this Article
Pubmed Style

Mohamed AMH, Algam SEA, Hussein ARME, Elkhidir IM, Enan KA. Molecular Detection of Leptospira in Pediatric Aseptic Meningitis. J Microbiol Infect Dis. 2022; 12(1): 35-37 . doi:10.5799/jmid.1086212

Web Style

Mohamed AMH, Algam SEA, Hussein ARME, Elkhidir IM, Enan KA. Molecular Detection of Leptospira in Pediatric Aseptic Meningitis. https://www.jmidonline.org/?mno=302657210 [Access: January 09, 2025]. doi:10.5799/jmid.1086212

AMA (American Medical Association) Style

Mohamed AMH, Algam SEA, Hussein ARME, Elkhidir IM, Enan KA. Molecular Detection of Leptospira in Pediatric Aseptic Meningitis. J Microbiol Infect Dis. 2022; 12(1): 35-37 . doi:10.5799/jmid.1086212


Vancouver/ICMJE Style

Mohamed AMH, Algam SEA, Hussein ARME, Elkhidir IM, Enan KA. Molecular Detection of Leptospira in Pediatric Aseptic Meningitis. J Microbiol Infect Dis. (2022), [cited January 09, 2025]; 12(1): 35-37 . doi:10.5799/jmid.1086212


Harvard Style

Mohamed, A. M. H., Algam, . S. E. A., Hussein, . A. R. M. E., Elkhidir, . I. M. & Enan, . K. A. (2022) Molecular Detection of Leptospira in Pediatric Aseptic Meningitis. J Microbiol Infect Dis, 12 (1), 35-37 . doi:10.5799/jmid.1086212


Turabian Style

Mohamed, Ahmed M. H., Sami E. A. Algam, Abdel Rahim M El Hussein, Isam M Elkhidir, and Khalid A Enan. 2022. Molecular Detection of Leptospira in Pediatric Aseptic Meningitis. Journal of Microbiology and Infectious Diseases, 12 (1), 35-37 . doi:10.5799/jmid.1086212


Chicago Style

Mohamed, Ahmed M. H., Sami E. A. Algam, Abdel Rahim M El Hussein, Isam M Elkhidir, and Khalid A Enan. "Molecular Detection of Leptospira in Pediatric Aseptic Meningitis." Journal of Microbiology and Infectious Diseases 12 (2022), 35-37 . doi:10.5799/jmid.1086212


MLA (The Modern Language Association) Style

Mohamed, Ahmed M. H., Sami E. A. Algam, Abdel Rahim M El Hussein, Isam M Elkhidir, and Khalid A Enan. "Molecular Detection of Leptospira in Pediatric Aseptic Meningitis." Journal of Microbiology and Infectious Diseases 12.1 (2022), 35-37 . Print. doi:10.5799/jmid.1086212


APA (American Psychological Association) Style

Mohamed, A. M. H., Algam, . S. E. A., Hussein, . A. R. M. E., Elkhidir, . I. M. & Enan, . K. A. (2022) Molecular Detection of Leptospira in Pediatric Aseptic Meningitis. Journal of Microbiology and Infectious Diseases, 12 (1), 35-37 . doi:10.5799/jmid.1086212


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All correspondence should be addressed to:

Prof. Ibrahim Eldaghayes

Editor-in-Chief

Journal of Microbiology and Infectious Diseases

Department of Microbiology and Parasitology 

Faculty of Veterinary Medicine

University of Tripoli

P.O. Box 13662, Tripoli, Libya