E-ISSN 2146-9369 | ISSN 2146-3158
 
2024, Vol: 14, Issue: 4
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Research Article 


Vertical Virus Transmission from SARS-CoV-2-positive Mothers to Neonates: An Experience at Tertiary Care Hospital

Neha Singh, Nikita Sherwani, Jyoti Jaiswal, Tripti Nagaria, Arvind Neral, Onkar Khandwal.


Cited By:5

Abstract
Objectives: The coronavirus disease 2019 (COVID-19) outbreak is evolving rapidly worldwide. However, little is known about the association between pregnant women with COVID-19 and its transmission to neonates. This investigation aimed to see if COVID-19 infection could be transmitted vertically into the uterus.
Methods: We conducted a prospective observational study. 48 COVID-19 infected mothers were enrolled during their third trimester. A qRT-PCR assay of the nasal and oropharyngeal swab samples was performed to confirm positive for COVID-19 infection as per WHO protocol. In addition, characteristics of pregnant women with confirmed SARS -CoV-2 infection and newborns were documented.
Results: Forty-eight expectant mothers, 10 (20.8%) were found symptomatic, and 38 (79.2%) were asymptomatic, with COVID-19 infection were delivered (33 cesarean section & 15 vaginal deliveries). One female child (4.1%) out of 48 newborns was initially diagnosed with COVID-19 infection based on a nucleic acid qRT-PCR. The female child showed no or negligible signs and recovered completely, whereas 47 neonates (95.9%) confirmed negative. None of the mothers or neonates died from COVID-19 related pulmonary problems.
Conclusion: There is insufficient evidence on vertical virologic transmission of COVID-19 infection during the third trimester of pregnancy. Additionally, research and surveillance involving adequate testing of samples of placental tissue, breast milk, vaginal swab, amniotic fluid, and cord blood will be needed to establish the possibility of vertical transmission of infection. J Microbiol Infect Dis 2022; 12(1):1-5.

Key words: Coronavirus, COVID-19, Neonate, Pregnant mothers, SARS-CoV-2, Vertical transmission


 
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How to Cite this Article
Pubmed Style

Singh N, Sherwani N, Jaiswal J, Nagaria T, Neral A, Khandwal O. Vertical Virus Transmission from SARS-CoV-2-positive Mothers to Neonates: An Experience at Tertiary Care Hospital. J Microbiol Infect Dis. 2022; 12(1): 1-5 . doi:10.5799/jmid.1085903

Web Style

Singh N, Sherwani N, Jaiswal J, Nagaria T, Neral A, Khandwal O. Vertical Virus Transmission from SARS-CoV-2-positive Mothers to Neonates: An Experience at Tertiary Care Hospital. https://www.jmidonline.org/?mno=302657106 [Access: January 09, 2025]. doi:10.5799/jmid.1085903

AMA (American Medical Association) Style

Singh N, Sherwani N, Jaiswal J, Nagaria T, Neral A, Khandwal O. Vertical Virus Transmission from SARS-CoV-2-positive Mothers to Neonates: An Experience at Tertiary Care Hospital. J Microbiol Infect Dis. 2022; 12(1): 1-5 . doi:10.5799/jmid.1085903


Vancouver/ICMJE Style

Singh N, Sherwani N, Jaiswal J, Nagaria T, Neral A, Khandwal O. Vertical Virus Transmission from SARS-CoV-2-positive Mothers to Neonates: An Experience at Tertiary Care Hospital. J Microbiol Infect Dis. (2022), [cited January 09, 2025]; 12(1): 1-5 . doi:10.5799/jmid.1085903


Harvard Style

Singh, N., Sherwani, . N., Jaiswal, . J., Nagaria, . T., Neral, . A. & Khandwal, . O. (2022) Vertical Virus Transmission from SARS-CoV-2-positive Mothers to Neonates: An Experience at Tertiary Care Hospital. J Microbiol Infect Dis, 12 (1), 1-5 . doi:10.5799/jmid.1085903


Turabian Style

Singh, Neha, Nikita Sherwani, Jyoti Jaiswal, Tripti Nagaria, Arvind Neral, and Onkar Khandwal. 2022. Vertical Virus Transmission from SARS-CoV-2-positive Mothers to Neonates: An Experience at Tertiary Care Hospital. Journal of Microbiology and Infectious Diseases, 12 (1), 1-5 . doi:10.5799/jmid.1085903


Chicago Style

Singh, Neha, Nikita Sherwani, Jyoti Jaiswal, Tripti Nagaria, Arvind Neral, and Onkar Khandwal. "Vertical Virus Transmission from SARS-CoV-2-positive Mothers to Neonates: An Experience at Tertiary Care Hospital." Journal of Microbiology and Infectious Diseases 12 (2022), 1-5 . doi:10.5799/jmid.1085903


MLA (The Modern Language Association) Style

Singh, Neha, Nikita Sherwani, Jyoti Jaiswal, Tripti Nagaria, Arvind Neral, and Onkar Khandwal. "Vertical Virus Transmission from SARS-CoV-2-positive Mothers to Neonates: An Experience at Tertiary Care Hospital." Journal of Microbiology and Infectious Diseases 12.1 (2022), 1-5 . Print. doi:10.5799/jmid.1085903


APA (American Psychological Association) Style

Singh, N., Sherwani, . N., Jaiswal, . J., Nagaria, . T., Neral, . A. & Khandwal, . O. (2022) Vertical Virus Transmission from SARS-CoV-2-positive Mothers to Neonates: An Experience at Tertiary Care Hospital. Journal of Microbiology and Infectious Diseases, 12 (1), 1-5 . doi:10.5799/jmid.1085903


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Journal of Microbiology and Infectious Diseases (JMID) is an international "peer review" journal in microbiology, infectious diseases, virology, ... Read more.



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All correspondence should be addressed to:

Prof. Ibrahim Eldaghayes

Editor-in-Chief

Journal of Microbiology and Infectious Diseases

Department of Microbiology and Parasitology 

Faculty of Veterinary Medicine

University of Tripoli

P.O. Box 13662, Tripoli, Libya