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Research Article 


Epidemiology of Antimicrobial Resistance among Escherichia coli Strains in Trans-Nzoia County, Kenya

Collins Kibenei Kipkorir, Philip Bett, Patrick O. Onyango, David Miruka Onyango, Cyrus Ayieko, Paul Oyieng Ang 'ienda.


Cited By:15

Abstract
ABSTRACT
Objective: This study aimed to determine prevalence, antimicrobial susceptibility profile and the genetic basis to antimicrobial resistance, targeting blaTEM gene expression of diarrheagenic Escherichia coli among patients suffering from gastroenteritis in Kitale County Referral Hospital. Methods: A cross-sectional study design was adopted. A total of 103 fecal specimens were collected from participants ranging in age from two weeks to 82 years. E. coli was isolated and identified based on phenotypic and biochemical properties. Antimicrobial susceptibility was determined by Kirby-Bauer disk diffusion method. Polymerase chain reaction was used to detect the presence of blaTEM gene. Results: The prevalence of E. coli was 90.2% and age of the patient explained 53% of variation in prevalence. Isolates of diarrheagenic E. coli showed varied degree of susceptibility with sulfamethoxazole at 97%, co-trimoxazole 96%, ampicillin 84%, chloramphenicol 27%, tetracycline 16%, kanamycin 10% and streptomycin 9%. However, E. coli was highly sensitive to gentamicin at 96.8%. Approximately 42.2% of E. coli isolates were multidrug resistant to sulfamethoxazole, co-trimoxazole, ampicillin, chloramphenicol, tetracycline, kanamycin and streptomycin. All isolates that were resistant to ampicillin harbored blaTEM gene suggesting genetic mediation. Conclusion: The observed pattern of resistance to antibiotics points to the need to regulate their use and arrest buildup of resistant genes within the population. J Microbiol Infect Dis 2016;6(3): 107-112.


 
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How to Cite this Article
Pubmed Style

Kipkorir CK, Bett P, Onyango PO, Onyango DM, Ayieko C, Ienda POA. Epidemiology of Antimicrobial Resistance among Escherichia coli Strains in Trans-Nzoia County, Kenya. J Microbiol Infect Dis. 2016; 6(3): 107-112 . doi:10.5799/jmid.328966

Web Style

Kipkorir CK, Bett P, Onyango PO, Onyango DM, Ayieko C, Ienda POA. Epidemiology of Antimicrobial Resistance among Escherichia coli Strains in Trans-Nzoia County, Kenya. https://www.jmidonline.org/?mno=302657003 [Access: April 10, 2025]. doi:10.5799/jmid.328966

AMA (American Medical Association) Style

Kipkorir CK, Bett P, Onyango PO, Onyango DM, Ayieko C, Ienda POA. Epidemiology of Antimicrobial Resistance among Escherichia coli Strains in Trans-Nzoia County, Kenya. J Microbiol Infect Dis. 2016; 6(3): 107-112 . doi:10.5799/jmid.328966


Vancouver/ICMJE Style

Kipkorir CK, Bett P, Onyango PO, Onyango DM, Ayieko C, Ienda POA. Epidemiology of Antimicrobial Resistance among Escherichia coli Strains in Trans-Nzoia County, Kenya. J Microbiol Infect Dis. (2016), [cited April 10, 2025]; 6(3): 107-112 . doi:10.5799/jmid.328966


Harvard Style

Kipkorir, C. K., Bett, . P., Onyango, . P. O., Onyango, . D. M., Ayieko, . C. & Ienda, . P. O. A. (2016) Epidemiology of Antimicrobial Resistance among Escherichia coli Strains in Trans-Nzoia County, Kenya. J Microbiol Infect Dis, 6 (3), 107-112 . doi:10.5799/jmid.328966


Turabian Style

Kipkorir, Collins Kibenei, Philip Bett, Patrick O. Onyango, David Miruka Onyango, Cyrus Ayieko, and Paul Oyieng Ang Ienda. 2016. Epidemiology of Antimicrobial Resistance among Escherichia coli Strains in Trans-Nzoia County, Kenya. Journal of Microbiology and Infectious Diseases, 6 (3), 107-112 . doi:10.5799/jmid.328966


Chicago Style

Kipkorir, Collins Kibenei, Philip Bett, Patrick O. Onyango, David Miruka Onyango, Cyrus Ayieko, and Paul Oyieng Ang Ienda. "Epidemiology of Antimicrobial Resistance among Escherichia coli Strains in Trans-Nzoia County, Kenya." Journal of Microbiology and Infectious Diseases 6 (2016), 107-112 . doi:10.5799/jmid.328966


MLA (The Modern Language Association) Style

Kipkorir, Collins Kibenei, Philip Bett, Patrick O. Onyango, David Miruka Onyango, Cyrus Ayieko, and Paul Oyieng Ang Ienda. "Epidemiology of Antimicrobial Resistance among Escherichia coli Strains in Trans-Nzoia County, Kenya." Journal of Microbiology and Infectious Diseases 6.3 (2016), 107-112 . Print. doi:10.5799/jmid.328966


APA (American Psychological Association) Style

Kipkorir, C. K., Bett, . P., Onyango, . P. O., Onyango, . D. M., Ayieko, . C. & Ienda, . P. O. A. (2016) Epidemiology of Antimicrobial Resistance among Escherichia coli Strains in Trans-Nzoia County, Kenya. Journal of Microbiology and Infectious Diseases, 6 (3), 107-112 . doi:10.5799/jmid.328966


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Journal of Microbiology and Infectious Diseases

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