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Research Article 


Evaluation of diagnostic tests for visceral leishmaniasis in Iran: a systematic review and meta-analysis

Assad Mirzaei, Azar Najafi, Entezar Abbasi Somar, Kourosh Sayehmiri, Hamidreza Majidiani.


Abstract
Objective: There exist various diagnostic tests to detect visceral leishmaniasis, but the most efficient ones have not been demonstrated yet. Herein, we evaluated the accuracy of these diagnostic tests in Iran.
Methodology: English and Persian database searching was done from 1993 to 2016. According to heterogeneity of the studies, estimations of the study were pooled by random-effects model. Totally, twenty investigations were eligible for current review with 2115 patients as pooled sample size.
Results: The overall pooled estimate of sensitivity and specificity for all diagnostic tests were 0.92 ([95% CI = 0.90–0.95]) and 0.92 ([95% CI = 0.89–0.94]), respectively. Also, the separate sensitivity and specificity of each test were as follow: PCR: 1.00 ([95% CI = 0.99–1.01]) and 0.37 ([95% CI = 0.25–0.49]); DAT: 0.93 ([95% CI = 0.89–0.96]) and 0.92 ([95% CI = 0.89–0.94]); ELISA: 0.78 ([95% CI = 0.47–1.09]) and 1.00 ([95% CI = 0.99–1.01]) as well as IFA: 0.50 ([95% CI = 0.29–0.72]) and 0.96 ([95% CI = 0.95–0.97]).
Conclusions: The specificity and sensitivity of PCR and DAT as molecular and serological tests, respectively, are remarkable to detect visceral leishmaniasis; hence, it is highly recommended to simultaneously employ these diagnostic tests for this widespread infection. J Microbiol Infect Dis 2019; 9(1): 16-22.

Key words: Visceral Leishmaniasis, sensitivity, specificity, diagnostic tests, L. infantum, Iran


 
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How to Cite this Article
Pubmed Style

Mirzaei A, Najafi A, Somar EA, Sayehmiri K, Majidiani H. Evaluation of diagnostic tests for visceral leishmaniasis in Iran: a systematic review and meta-analysis. J Microbiol Infect Dis. 2019; 9(1): 16-22 . doi:10.5799/jmid.537150

Web Style

Mirzaei A, Najafi A, Somar EA, Sayehmiri K, Majidiani H. Evaluation of diagnostic tests for visceral leishmaniasis in Iran: a systematic review and meta-analysis. https://www.jmidonline.org/?mno=302656974 [Access: January 09, 2025]. doi:10.5799/jmid.537150

AMA (American Medical Association) Style

Mirzaei A, Najafi A, Somar EA, Sayehmiri K, Majidiani H. Evaluation of diagnostic tests for visceral leishmaniasis in Iran: a systematic review and meta-analysis. J Microbiol Infect Dis. 2019; 9(1): 16-22 . doi:10.5799/jmid.537150


Vancouver/ICMJE Style

Mirzaei A, Najafi A, Somar EA, Sayehmiri K, Majidiani H. Evaluation of diagnostic tests for visceral leishmaniasis in Iran: a systematic review and meta-analysis. J Microbiol Infect Dis. (2019), [cited January 09, 2025]; 9(1): 16-22 . doi:10.5799/jmid.537150


Harvard Style

Mirzaei, A., Najafi, . A., Somar, . E. A., Sayehmiri, . K. & Majidiani, . H. (2019) Evaluation of diagnostic tests for visceral leishmaniasis in Iran: a systematic review and meta-analysis. J Microbiol Infect Dis, 9 (1), 16-22 . doi:10.5799/jmid.537150


Turabian Style

Mirzaei, Assad, Azar Najafi, Entezar Abbasi Somar, Kourosh Sayehmiri, and Hamidreza Majidiani. 2019. Evaluation of diagnostic tests for visceral leishmaniasis in Iran: a systematic review and meta-analysis. Journal of Microbiology and Infectious Diseases, 9 (1), 16-22 . doi:10.5799/jmid.537150


Chicago Style

Mirzaei, Assad, Azar Najafi, Entezar Abbasi Somar, Kourosh Sayehmiri, and Hamidreza Majidiani. "Evaluation of diagnostic tests for visceral leishmaniasis in Iran: a systematic review and meta-analysis." Journal of Microbiology and Infectious Diseases 9 (2019), 16-22 . doi:10.5799/jmid.537150


MLA (The Modern Language Association) Style

Mirzaei, Assad, Azar Najafi, Entezar Abbasi Somar, Kourosh Sayehmiri, and Hamidreza Majidiani. "Evaluation of diagnostic tests for visceral leishmaniasis in Iran: a systematic review and meta-analysis." Journal of Microbiology and Infectious Diseases 9.1 (2019), 16-22 . Print. doi:10.5799/jmid.537150


APA (American Psychological Association) Style

Mirzaei, A., Najafi, . A., Somar, . E. A., Sayehmiri, . K. & Majidiani, . H. (2019) Evaluation of diagnostic tests for visceral leishmaniasis in Iran: a systematic review and meta-analysis. Journal of Microbiology and Infectious Diseases, 9 (1), 16-22 . doi:10.5799/jmid.537150


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Journal of Microbiology and Infectious Diseases

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