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2024, Vol: 14, Issue: 4
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Research Article 


Emergence of Pan drug resistance amongst gram negative bacteria! The First case series from India

Abdul Ghafur, Vidya Lakshmi, Priyadarshini Kannain, Thirunarayan Ma.


Cited By:57

Abstract
Background: Increasing prevalence of carbapenem resistant Gram negative bacteria is a serious clinical and public health challenge. Bacteria resistant to all available antibiotics (Pan Drug Resistance) herald the onset of post antibiotics era. We hereby report clinical profile of 13 patients with pan drug resistant gram negative isolates.
Methods: Retrospective analysis of 13 patients with pan drug resistant gram negative isolates over the last 18 months was done by medical records review. Identification of the isolates and susceptibility testing was done using VITEK auto analyzer in concordance with the corresponding CLSI guidelines.
Results: Out of four patients with bacteraemic isolates, three patients received colistin based combination therapy. Though two of these patients had microbiologic clearance, all the three died. Out of the 9 patients with non bacteraemic isolates, 4 had infection and 5 had colonization. Three (out of four) were treated with combination therapy including colistin and one patient received colistin monotherapy. All four patients had microbiological clearance. Three patients had clinical cure and were discharged. One patient later developed bacteraemia and died.
Conclusion: Infections, particularly blood stream with pan drug resistant organisms has a higher mortality. Urgent studies to reevaluate existing therapeutic options and research into new antibiotic molecules are the need of the hour. J Microbiol Infect Dis 2014; 4(3): 87-90


 
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How to Cite this Article
Pubmed Style

Ghafur A, Lakshmi V, Kannain P, Ma T. Emergence of Pan drug resistance amongst gram negative bacteria! The First case series from India. J Microbiol Infect Dis. 2014; 4(3): 86-91 . doi:10.5799/jmid2014.03.0145

Web Style

Ghafur A, Lakshmi V, Kannain P, Ma T. Emergence of Pan drug resistance amongst gram negative bacteria! The First case series from India. https://www.jmidonline.org/?mno=302656946 [Access: January 09, 2025]. doi:10.5799/jmid2014.03.0145

AMA (American Medical Association) Style

Ghafur A, Lakshmi V, Kannain P, Ma T. Emergence of Pan drug resistance amongst gram negative bacteria! The First case series from India. J Microbiol Infect Dis. 2014; 4(3): 86-91 . doi:10.5799/jmid2014.03.0145


Vancouver/ICMJE Style

Ghafur A, Lakshmi V, Kannain P, Ma T. Emergence of Pan drug resistance amongst gram negative bacteria! The First case series from India. J Microbiol Infect Dis. (2014), [cited January 09, 2025]; 4(3): 86-91 . doi:10.5799/jmid2014.03.0145


Harvard Style

Ghafur, A., Lakshmi, . V., Kannain, . P. & Ma, . T. (2014) Emergence of Pan drug resistance amongst gram negative bacteria! The First case series from India. J Microbiol Infect Dis, 4 (3), 86-91 . doi:10.5799/jmid2014.03.0145


Turabian Style

Ghafur, Abdul, Vidya Lakshmi, Priyadarshini Kannain, and Thirunarayan Ma. 2014. Emergence of Pan drug resistance amongst gram negative bacteria! The First case series from India. Journal of Microbiology and Infectious Diseases, 4 (3), 86-91 . doi:10.5799/jmid2014.03.0145


Chicago Style

Ghafur, Abdul, Vidya Lakshmi, Priyadarshini Kannain, and Thirunarayan Ma. "Emergence of Pan drug resistance amongst gram negative bacteria! The First case series from India." Journal of Microbiology and Infectious Diseases 4 (2014), 86-91 . doi:10.5799/jmid2014.03.0145


MLA (The Modern Language Association) Style

Ghafur, Abdul, Vidya Lakshmi, Priyadarshini Kannain, and Thirunarayan Ma. "Emergence of Pan drug resistance amongst gram negative bacteria! The First case series from India." Journal of Microbiology and Infectious Diseases 4.3 (2014), 86-91 . Print. doi:10.5799/jmid2014.03.0145


APA (American Psychological Association) Style

Ghafur, A., Lakshmi, . V., Kannain, . P. & Ma, . T. (2014) Emergence of Pan drug resistance amongst gram negative bacteria! The First case series from India. Journal of Microbiology and Infectious Diseases, 4 (3), 86-91 . doi:10.5799/jmid2014.03.0145


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