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2025, Vol: 15, Issue: 1
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Research Article 


Sensitivity pattern of Gram negative bacteria to the new β-lactam/β-lactamase inhibitor combination: Cefepime/tazobactam

Abdul Ghafur, Ramasamy Pushparaju, Krishnamurthy Rajkumar, Durairajan Sureshkumar.


Cited By:17

Abstract
Objectives: Increasing prevalence of carbapenem-resistant Gram negative bacteria has prompted researchers to explore alternative antibiotic options. Different ß-lactam/ß-lactamase inhibitor (BL/BLI) combinations are used in many countries, as a carbapenem saving strategy. The purpose of our study was to evaluate the sensitivity pattern of cefepime/tazobactam combination in comparison to piperacillin/tazobactam, cefoperazone/sulbactam, cefepime and carbapenem agents.
Materials and methods: We conducted retrospective analysis of the sensitivity pattern of Gram negative bacterial isolates in Apollo Speciality Hospital; a 300 bedded, tertiary care Oncology, Neurosurgical and Orthopaedic Centre in South India.
Results: Out of the 1003 Gram negative, non-repetitive isolates collected over a period of one year; 60.5% were sensitive to piperacillin-tazobactam, 46.2% to cefepime, 80.4% to cefepime/tazobactam, 71.3% to cefoperazone-sulbactam, 79.1% to imipenem and 78.2% to meropenem. Addition of tazobactam increased the susceptibility of cefepime from 46.2% to 80.4% in gram negative isolates in general; from 34.4 to 87.9% in E. coli, from 42.3 to 81.0% to Klebsiella, from 72.0 to 81.4% in Pseudomonas and 17.2-54.5% to Acinetobacter.
Conclusion: Cefepime/tazobactam provided a better invitro sensitivity profile than other BL-BLI combinations studied. This in vitro data needs to be confirmed by clinical studies. J Microbiol Infect Dis 2012; 2(1): 5-8

Key words: Cefepime/tazobactam, carbapenem sparing strategy, Gram negative resistance, BL-BLI combination.


 
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How to Cite this Article
Pubmed Style

Ghafur A, Pushparaju R, Rajkumar K, Sureshkumar D. Sensitivity pattern of Gram negative bacteria to the new β-lactam/β-lactamase inhibitor combination: Cefepime/tazobactam. J Microbiol Infect Dis. 2012; 2(1): 5-8 . doi:10.5799/jmid2012.01.0033

Web Style

Ghafur A, Pushparaju R, Rajkumar K, Sureshkumar D. Sensitivity pattern of Gram negative bacteria to the new β-lactam/β-lactamase inhibitor combination: Cefepime/tazobactam. https://www.jmidonline.org/?mno=302656945 [Access: April 11, 2025]. doi:10.5799/jmid2012.01.0033

AMA (American Medical Association) Style

Ghafur A, Pushparaju R, Rajkumar K, Sureshkumar D. Sensitivity pattern of Gram negative bacteria to the new β-lactam/β-lactamase inhibitor combination: Cefepime/tazobactam. J Microbiol Infect Dis. 2012; 2(1): 5-8 . doi:10.5799/jmid2012.01.0033


Vancouver/ICMJE Style

Ghafur A, Pushparaju R, Rajkumar K, Sureshkumar D. Sensitivity pattern of Gram negative bacteria to the new β-lactam/β-lactamase inhibitor combination: Cefepime/tazobactam. J Microbiol Infect Dis. (2012), [cited April 11, 2025]; 2(1): 5-8 . doi:10.5799/jmid2012.01.0033


Harvard Style

Ghafur, A., Pushparaju, . R., Rajkumar, . K. & Sureshkumar, . D. (2012) Sensitivity pattern of Gram negative bacteria to the new β-lactam/β-lactamase inhibitor combination: Cefepime/tazobactam. J Microbiol Infect Dis, 2 (1), 5-8 . doi:10.5799/jmid2012.01.0033


Turabian Style

Ghafur, Abdul, Ramasamy Pushparaju, Krishnamurthy Rajkumar, and Durairajan Sureshkumar. 2012. Sensitivity pattern of Gram negative bacteria to the new β-lactam/β-lactamase inhibitor combination: Cefepime/tazobactam. Journal of Microbiology and Infectious Diseases, 2 (1), 5-8 . doi:10.5799/jmid2012.01.0033


Chicago Style

Ghafur, Abdul, Ramasamy Pushparaju, Krishnamurthy Rajkumar, and Durairajan Sureshkumar. "Sensitivity pattern of Gram negative bacteria to the new β-lactam/β-lactamase inhibitor combination: Cefepime/tazobactam." Journal of Microbiology and Infectious Diseases 2 (2012), 5-8 . doi:10.5799/jmid2012.01.0033


MLA (The Modern Language Association) Style

Ghafur, Abdul, Ramasamy Pushparaju, Krishnamurthy Rajkumar, and Durairajan Sureshkumar. "Sensitivity pattern of Gram negative bacteria to the new β-lactam/β-lactamase inhibitor combination: Cefepime/tazobactam." Journal of Microbiology and Infectious Diseases 2.1 (2012), 5-8 . Print. doi:10.5799/jmid2012.01.0033


APA (American Psychological Association) Style

Ghafur, A., Pushparaju, . R., Rajkumar, . K. & Sureshkumar, . D. (2012) Sensitivity pattern of Gram negative bacteria to the new β-lactam/β-lactamase inhibitor combination: Cefepime/tazobactam. Journal of Microbiology and Infectious Diseases, 2 (1), 5-8 . doi:10.5799/jmid2012.01.0033


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