E-ISSN 2146-9369 | ISSN 2146-3158
 
2024, Vol: 14, Issue: 1
14 / 1Current Issue ArchiveAims and ScopeAbstracting & IndexingMost Accessed ArticlesMost Downloaded ArticlesMost Cited Articles

Research Article


Prevalence of carbapenemase-producing organisms among patients admitted to intensive care unit in a tertiary hospital in Benin city, Nigeria

Ephraim E. Ibadin, Helen O. Ogefere, Richard Omoregie, Jerry Igunma.


Abstract
Aim:
The study aimed to determine the prevalence of carbapenemase-producing organisms (CPOs) causing clinical infections among intensive care unit (ICU) patients at the University of Benin Teaching Hospital (UBTH), Benin City, Nigeria.
Methods:
Gram negative bacterial isolates recovered from clinical specimens of patients admitted at the ICU of the hospital during the study period were identified using Microbact 20E and antimicrobial susceptibility tests carried out. Carbapenem resistant isolates were thereafter screened phenotypically for carbapenemase production, CPOs were subsequently screened using PCR for the following genes; NDM, VIM, KPC and OXA-48-like.
Results:
A total of 64 clinical specimens were received during the study period. Of this number, 26 (40.6%) were culture positive for Enterobacterales (21.9%) and non-fermenters (18.8%). Amikacin showed the best susceptibility profile with 81.5% overall activity against all isolates, the carbapenems showed moderate activity with 66.7% while the third generation cephalosporins were poorly active (37%) against all bacterial isolates. Carbapenemase activity was observed in 9 isolates (14.1%), one isolate of E. cloacae was VIM positive while 62.5% and 25% of CP-P. aeruginosa were NDM and VIM positive respectively.
Conclusion:
Carbapenemase-producing-P. aeruginosa was the leading cause of infections among ICU patients in Benin City, Nigeria. There is therefore need for surveillance, IPC measures and adherence of antimicrobial stewardship guidelines at institutional and national levels.

Key words: Carbapenemase, Resistance, Clinical infection, Intensive care unit, Bacterial isolates


 
ARTICLE TOOLS
Abstract
PDF Fulltext
HTML Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Ephraim E. Ibadin
Articles by Helen O. Ogefere
Articles by Richard Omoregie
Articles by Jerry Igunma
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

Ibadin EE, Ogefere HO, Omoregie R, Igunma J. Prevalence of carbapenemase-producing organisms among patients admitted to intensive care unit in a tertiary hospital in Benin city, Nigeria. J Microbiol Infect Dis. 2023; 13(2): 53-58. doi:10.5455/JMID.2023.v13.i2.2

Web Style

Ibadin EE, Ogefere HO, Omoregie R, Igunma J. Prevalence of carbapenemase-producing organisms among patients admitted to intensive care unit in a tertiary hospital in Benin city, Nigeria. https://www.jmidonline.org/?mno=302657411 [Access: April 30, 2024]. doi:10.5455/JMID.2023.v13.i2.2

AMA (American Medical Association) Style

Ibadin EE, Ogefere HO, Omoregie R, Igunma J. Prevalence of carbapenemase-producing organisms among patients admitted to intensive care unit in a tertiary hospital in Benin city, Nigeria. J Microbiol Infect Dis. 2023; 13(2): 53-58. doi:10.5455/JMID.2023.v13.i2.2


Vancouver/ICMJE Style

Ibadin EE, Ogefere HO, Omoregie R, Igunma J. Prevalence of carbapenemase-producing organisms among patients admitted to intensive care unit in a tertiary hospital in Benin city, Nigeria. J Microbiol Infect Dis. (2023), [cited April 30, 2024]; 13(2): 53-58. doi:10.5455/JMID.2023.v13.i2.2


Harvard Style

Ibadin, E. E., Ogefere, . H. O., Omoregie, . R. & Igunma, . J. (2023) Prevalence of carbapenemase-producing organisms among patients admitted to intensive care unit in a tertiary hospital in Benin city, Nigeria. J Microbiol Infect Dis, 13 (2), 53-58. doi:10.5455/JMID.2023.v13.i2.2


Turabian Style

Ibadin, Ephraim E., Helen O. Ogefere, Richard Omoregie, and Jerry Igunma. 2023. Prevalence of carbapenemase-producing organisms among patients admitted to intensive care unit in a tertiary hospital in Benin city, Nigeria. Journal of Microbiology and Infectious Diseases, 13 (2), 53-58. doi:10.5455/JMID.2023.v13.i2.2


Chicago Style

Ibadin, Ephraim E., Helen O. Ogefere, Richard Omoregie, and Jerry Igunma. "Prevalence of carbapenemase-producing organisms among patients admitted to intensive care unit in a tertiary hospital in Benin city, Nigeria." Journal of Microbiology and Infectious Diseases 13 (2023), 53-58. doi:10.5455/JMID.2023.v13.i2.2


MLA (The Modern Language Association) Style

Ibadin, Ephraim E., Helen O. Ogefere, Richard Omoregie, and Jerry Igunma. "Prevalence of carbapenemase-producing organisms among patients admitted to intensive care unit in a tertiary hospital in Benin city, Nigeria." Journal of Microbiology and Infectious Diseases 13.2 (2023), 53-58. Print. doi:10.5455/JMID.2023.v13.i2.2


APA (American Psychological Association) Style

Ibadin, E. E., Ogefere, . H. O., Omoregie, . R. & Igunma, . J. (2023) Prevalence of carbapenemase-producing organisms among patients admitted to intensive care unit in a tertiary hospital in Benin city, Nigeria. Journal of Microbiology and Infectious Diseases, 13 (2), 53-58. doi:10.5455/JMID.2023.v13.i2.2


Author LoginReviewer LoginAbout PublisherOpen Access PolicyEditorial PoliciesPeer Review PolicyPublication Ethics and Publication Malpractice StatementConflict of Interest PolicyPlagiarism PolicyProtection of Research Participants (Statement On Human And Animal Rights)Privacy PolicyCorrections, Retractions & Expressions of ConcernSelf-Archiving PoliciesDigital Archiving & Preservation PoliciesStatement of Informed ConsentAdvertising PolicyTerms of UseLicense InformationCopyright Information

About Journal of Microbiology and Infectious Diseases

Journal of Microbiology and Infectious Diseases (JMID) is an international "peer review" journal in microbiology, infectious diseases, virology, ... Read more.



For best results, please use Internet Explorer or Google Chrome.

Contact Information

All correspondence should be addressed to:

Prof. Ibrahim Eldaghayes

Editor-in-Chief

Journal of Microbiology and Infectious Diseases

Department of Microbiology and Parasitology 

Faculty of Veterinary Medicine

University of Tripoli

P.O. Box 13662, Tripoli, Libya