E-ISSN 2146-9369 | ISSN 2146-3158
 

Research Article 


Nosocomial infections in very low birth weight infants

V Vamsi Sivarama Raju, Jayashree Purkayastha, Leslie Lewis, Ramesh Bhat Y.

Cited By:1

Abstract
Objective: We aimed to find out the incidence and risk factors of nosocomial infections in VLBW neonates and to explore the microbiologic flora, sensitivity pattern and outcome.<br>Methods: A prospective, observational study was performed in a neonatal intensive care unit of a teaching hospital. VLBW infants excluding those diagnosed with early onset sepsis, admitted to the unit between August 2012 and March 2013 were followed up for evidence of nosocomial sepsis.<br>Results: Of 92 VLBW infants, 23 developed nosocomial sepsis, incidence rate being 25%. Decreasing birth weight (1251-1500 g, 10.9%; 1001-1250 g, 28%; 751-1000 g, 50%; P<.001) and gestational age (>33wks, 0%; 29-32wks, 21.3%; 26-28 wks, 66.7%; p<.001) were found to be associated with statistically significant increase in nosocomial sepsis rate.<br>On multivariate logistic regression, only peripherally inserted central catheter (PICC) line was independently associated with increased risk of nosocomial sepsis (aOR 13.33, 95% CI 3.58-49.5) in VLBW.<br>A predominance of Gram negative over Gram positive nosocomial sepsis (75% vs. 25%) with higher mortality in the Gram negative group (55% vs. 0%) was observed. Klebsiella pneumoniae was the predominant microbe (33.4%). All microbes were sensitive to first line antibiotics except Elizabeth kingia meningoseptica and one episode of K. pneumoniae. Seven (30.4%) VLBW neonates with nosocomial sepsis died.<br>Conclusions: Among VLBW infants, the incidence of nosocomial sepsis was 25%. Lower birth weight, lesser gestational age and PICC line were important risk factors. Gram negative nosocomial sepsis was associated with higher mortality compared to Gram positive sepsis. J Microbiol Infect Dis 2017; 7(1): 7-12

Key words: Neonates; Nosocomial sepsis; VLBW infants


 
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How to Cite this Article
Pubmed Style

V Vamsi Sivarama Raju, Jayashree Purkayastha, Leslie Lewis, Ramesh Bhat Y. Nosocomial infections in very low birth weight infants. J Microbiol Infect Dis. 2017; 7(1): 7-12 . doi:10.5799/jmid.328836


Web Style

V Vamsi Sivarama Raju, Jayashree Purkayastha, Leslie Lewis, Ramesh Bhat Y. Nosocomial infections in very low birth weight infants. https://www.jmidonline.org/?mno=302657184 [Access: February 03, 2024]. doi:10.5799/jmid.328836


AMA (American Medical Association) Style

V Vamsi Sivarama Raju, Jayashree Purkayastha, Leslie Lewis, Ramesh Bhat Y. Nosocomial infections in very low birth weight infants. J Microbiol Infect Dis. 2017; 7(1): 7-12 . doi:10.5799/jmid.328836



Vancouver/ICMJE Style

V Vamsi Sivarama Raju, Jayashree Purkayastha, Leslie Lewis, Ramesh Bhat Y. Nosocomial infections in very low birth weight infants. J Microbiol Infect Dis. (2017), [cited February 03, 2024]; 7(1): 7-12 . doi:10.5799/jmid.328836



Harvard Style

V Vamsi Sivarama Raju, Jayashree Purkayastha, Leslie Lewis, Ramesh Bhat Y (2017) Nosocomial infections in very low birth weight infants. J Microbiol Infect Dis, 7 (1), 7-12 . doi:10.5799/jmid.328836



Turabian Style

V Vamsi Sivarama Raju, Jayashree Purkayastha, Leslie Lewis, Ramesh Bhat Y. 2017. Nosocomial infections in very low birth weight infants. Journal of Microbiology and Infectious Diseases, 7 (1), 7-12 . doi:10.5799/jmid.328836



Chicago Style

V Vamsi Sivarama Raju, Jayashree Purkayastha, Leslie Lewis, Ramesh Bhat Y. "Nosocomial infections in very low birth weight infants." Journal of Microbiology and Infectious Diseases 7 (2017), 7-12 . doi:10.5799/jmid.328836



MLA (The Modern Language Association) Style

V Vamsi Sivarama Raju, Jayashree Purkayastha, Leslie Lewis, Ramesh Bhat Y. "Nosocomial infections in very low birth weight infants." Journal of Microbiology and Infectious Diseases 7.1 (2017), 7-12 . Print. doi:10.5799/jmid.328836



APA (American Psychological Association) Style

V Vamsi Sivarama Raju, Jayashree Purkayastha, Leslie Lewis, Ramesh Bhat Y (2017) Nosocomial infections in very low birth weight infants. Journal of Microbiology and Infectious Diseases, 7 (1), 7-12 . doi:10.5799/jmid.328836