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Research Article 


Tenofovir therapy in chronic hepatitis B infection: 48-week results from Izmir Province, Turkey

Sukran Kose, Gursel Ersan, Suheyla Serin Senger, Gulsun Akincioglu, Melda Ulusoy, Gulgun Akkoclu.

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Abstract
Objectives: The goal of therapy in chronic hepatitis B infection (CHB) is to impede liver injury by suppressing viral replication. The study was aimed to determine the eficacy of tenofovir (TDF) in CHB infection for 48 weeks.<br>Materials and methods: We retrospectively analyzed the data of 45 CHB patients treated by tenofovir. The patients were divided into two groups based on their hepatitis B e antigen status (HBeAg). Those who were eligible to therapy received TDF 300 mg once daily for 48 weeks. Serum alanine aminotransferase levels (ALT), hepatitis B virus DNA (HBV DNA), and viral serological markers were checked at three-month intervals. Liver biopsy scores were determined in all patients.<br>Results: The mean age ± standard deviation (SD) was 35.8 ± 17.0 years, 26 (57.8 %) were male, and seven patients (15.5%) were treatment-experienced by a nucleos(t)ide analogue before TDF. HBeAg was positive in 17 (37.8%) patients. At week 48 among HBeAg positive (HBeAg +) patients ' biochemical and virological response rates at month-3, -6 and -12 were 64.7%, and 100%, 70.6%, and 94.1%, and 88.2%, and 64.7%, respectively. The serological response in HBeAg + patients was 29.4%. For HBeAg negative (HBeAg -) patients; biochemical, and virological response rates were 64.3%, and 96.4% at month 3; 82.1%, and 96.4% at month 6; and 100%, and 85.7% at month 12, respectively. At week 48 both groups had signiicant virological response (p<0.001).<br>Conclusion: Treatment in CHB with TDF leads to HBV DNA suppression without evident resistance for 48-week, and is well tolerated. J Microbiol Infect Dis 2012; 2(3): 87-92


 
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How to Cite this Article
Pubmed Style

Sukran Kose, Gursel Ersan, Suheyla Serin Senger, Gulsun Akincioglu, Melda Ulusoy, Gulgun Akkoclu. Tenofovir therapy in chronic hepatitis B infection: 48-week results from Izmir Province, Turkey. J Microbiol Infect Dis. 2012; 2(3): 87-92 . doi:10.5799/jmid2012.03.0050

Web Style

Sukran Kose, Gursel Ersan, Suheyla Serin Senger, Gulsun Akincioglu, Melda Ulusoy, Gulgun Akkoclu. Tenofovir therapy in chronic hepatitis B infection: 48-week results from Izmir Province, Turkey. https://www.jmidonline.org/?mno=302657167 [Access: February 02, 2024]. doi:10.5799/jmid2012.03.0050

AMA (American Medical Association) Style

Sukran Kose, Gursel Ersan, Suheyla Serin Senger, Gulsun Akincioglu, Melda Ulusoy, Gulgun Akkoclu. Tenofovir therapy in chronic hepatitis B infection: 48-week results from Izmir Province, Turkey. J Microbiol Infect Dis. 2012; 2(3): 87-92 . doi:10.5799/jmid2012.03.0050


Vancouver/ICMJE Style

Sukran Kose, Gursel Ersan, Suheyla Serin Senger, Gulsun Akincioglu, Melda Ulusoy, Gulgun Akkoclu. Tenofovir therapy in chronic hepatitis B infection: 48-week results from Izmir Province, Turkey. J Microbiol Infect Dis. (2012), [cited February 02, 2024]; 2(3): 87-92 . doi:10.5799/jmid2012.03.0050


Harvard Style

Sukran Kose, Gursel Ersan, Suheyla Serin Senger, Gulsun Akincioglu, Melda Ulusoy, Gulgun Akkoclu (2012) Tenofovir therapy in chronic hepatitis B infection: 48-week results from Izmir Province, Turkey. J Microbiol Infect Dis, 2 (3), 87-92 . doi:10.5799/jmid2012.03.0050


Turabian Style

Sukran Kose, Gursel Ersan, Suheyla Serin Senger, Gulsun Akincioglu, Melda Ulusoy, Gulgun Akkoclu. 2012. Tenofovir therapy in chronic hepatitis B infection: 48-week results from Izmir Province, Turkey. Journal of Microbiology and Infectious Diseases, 2 (3), 87-92 . doi:10.5799/jmid2012.03.0050


Chicago Style

Sukran Kose, Gursel Ersan, Suheyla Serin Senger, Gulsun Akincioglu, Melda Ulusoy, Gulgun Akkoclu. "Tenofovir therapy in chronic hepatitis B infection: 48-week results from Izmir Province, Turkey." Journal of Microbiology and Infectious Diseases 2 (2012), 87-92 . doi:10.5799/jmid2012.03.0050


MLA (The Modern Language Association) Style

Sukran Kose, Gursel Ersan, Suheyla Serin Senger, Gulsun Akincioglu, Melda Ulusoy, Gulgun Akkoclu. "Tenofovir therapy in chronic hepatitis B infection: 48-week results from Izmir Province, Turkey." Journal of Microbiology and Infectious Diseases 2.3 (2012), 87-92 . Print. doi:10.5799/jmid2012.03.0050


APA (American Psychological Association) Style

Sukran Kose, Gursel Ersan, Suheyla Serin Senger, Gulsun Akincioglu, Melda Ulusoy, Gulgun Akkoclu (2012) Tenofovir therapy in chronic hepatitis B infection: 48-week results from Izmir Province, Turkey. Journal of Microbiology and Infectious Diseases, 2 (3), 87-92 . doi:10.5799/jmid2012.03.0050


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Journal of Microbiology and Infectious Diseases

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