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Research Article 


The follow-up results with sustained virologic response in chronic hepatitisC patients in Sanliurfa/Turkey

Suda Tekin Koruk, Ibrahim Koruk, Celal Calisir, Hasan Karsen.


Abstract
Objectives: The aim of the study was to evaluate sustained virological response (SVR) after treatment and factors that influence SVR among patients treated for chronic hepatitis C (CHC).
Materials and methods: The study was conducted in patients with CHC between April 2007 and March 2011, who had achieved SVR following treatment. They were treated with PEG IFN-α and ribavirin. Patients, whose end of treatment responses were obtained without a SVR, received a second course of treatment.
Results: A total of 124 patients, 61 female (49.2%) were enrolled in the study. The distribution of genotypes was: 102 patients with genotype 1 (82.3%) and 22 with genotype 2 (17.7%). SVR was achieved in 78 patients (62.9%) (67 during the first course and 11 in the second) were followed up for a mean duration of 18.4±8.5 months. Positive predictive factors on SVR were female gender (P=0.01), low initial viral load (P=0.01), early virological response (EVR) development (P<0.001) and infection with genotype 2 (P<0.001).
Conclusions: In conclusion, there was no recurrence of HCV infection beyond follow-up of 24 months in any of the patients who obtained SVR. Female gender, low initial viral load, development of EVR and infection with genotype 2 was determined to have a positive impact on SVR. J Microbiol Infect Dis 2012; 2(1): 14-20

Key words: Chronic hepatitis C, genotype, sustained virological response, therapy.


 
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How to Cite this Article
Pubmed Style

Koruk ST, Koruk I, Calisir C, Karsen H. The follow-up results with sustained virologic response in chronic hepatitisC patients in Sanliurfa/Turkey. J Microbiol Infect Dis. 2012; 2(1): 24-20 . doi:10.5799/jmid2012.01.0035

Web Style

Koruk ST, Koruk I, Calisir C, Karsen H. The follow-up results with sustained virologic response in chronic hepatitisC patients in Sanliurfa/Turkey. https://www.jmidonline.org/?mno=302657165 [Access: January 10, 2025]. doi:10.5799/jmid2012.01.0035

AMA (American Medical Association) Style

Koruk ST, Koruk I, Calisir C, Karsen H. The follow-up results with sustained virologic response in chronic hepatitisC patients in Sanliurfa/Turkey. J Microbiol Infect Dis. 2012; 2(1): 24-20 . doi:10.5799/jmid2012.01.0035


Vancouver/ICMJE Style

Koruk ST, Koruk I, Calisir C, Karsen H. The follow-up results with sustained virologic response in chronic hepatitisC patients in Sanliurfa/Turkey. J Microbiol Infect Dis. (2012), [cited January 10, 2025]; 2(1): 24-20 . doi:10.5799/jmid2012.01.0035


Harvard Style

Koruk, S. T., Koruk, . I., Calisir, . C. & Karsen, . H. (2012) The follow-up results with sustained virologic response in chronic hepatitisC patients in Sanliurfa/Turkey. J Microbiol Infect Dis, 2 (1), 24-20 . doi:10.5799/jmid2012.01.0035


Turabian Style

Koruk, Suda Tekin, Ibrahim Koruk, Celal Calisir, and Hasan Karsen. 2012. The follow-up results with sustained virologic response in chronic hepatitisC patients in Sanliurfa/Turkey. Journal of Microbiology and Infectious Diseases, 2 (1), 24-20 . doi:10.5799/jmid2012.01.0035


Chicago Style

Koruk, Suda Tekin, Ibrahim Koruk, Celal Calisir, and Hasan Karsen. "The follow-up results with sustained virologic response in chronic hepatitisC patients in Sanliurfa/Turkey." Journal of Microbiology and Infectious Diseases 2 (2012), 24-20 . doi:10.5799/jmid2012.01.0035


MLA (The Modern Language Association) Style

Koruk, Suda Tekin, Ibrahim Koruk, Celal Calisir, and Hasan Karsen. "The follow-up results with sustained virologic response in chronic hepatitisC patients in Sanliurfa/Turkey." Journal of Microbiology and Infectious Diseases 2.1 (2012), 24-20 . Print. doi:10.5799/jmid2012.01.0035


APA (American Psychological Association) Style

Koruk, S. T., Koruk, . I., Calisir, . C. & Karsen, . H. (2012) The follow-up results with sustained virologic response in chronic hepatitisC patients in Sanliurfa/Turkey. Journal of Microbiology and Infectious Diseases, 2 (1), 24-20 . doi:10.5799/jmid2012.01.0035


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