E-ISSN 2146-9369 | ISSN 2146-3158
 
2024, Vol: 14, Issue: 1
14 / 1Current Issue ArchiveAims and ScopeAbstracting & IndexingMost Accessed ArticlesMost Downloaded ArticlesMost Cited Articles

Research Article 


Comparison of fluconazole and posaconazole for fungal prophylaxis in high-risk patients with hematological malignity

Selçuk Kaya, Mehmet Sönmez, Iftihar Köksal, Eda Gençalioğlu, Mustafa Yılmaz, Gürdal Yılmaz.

Cited By:3

Abstract
Objective: To compare the frequency of fungal infection and mortality rates in patients with hematological malignity and receiving either flucanazole (FLU) or posaconazole (POS) prophylaxis.<br>Methods: This retrospective, observational study investigated fungal prophylaxis in patients with a high risk of invasive fungal infections (IFIs) and diagnosed with hematological malignity at our hospital hematology clinic between 01.01.2011 and 01.01.2013. FLU (n=70) was the prophylactic regimen between 2011 and 2012 which was replaced by POS (n=35) in the following period. The incidence and mortality rates of IFIs developing in the two periods were compared.<br>Results: The incidence of IFI in patients administered FLU prophylaxis was 22/70 (31%), compared to 13/35 (37%) in the patients receiving POS. Incidence of invasive pulmonary aspergillosis (IPA) in the FLU group was 21/70 (31%), compared to 9/35 (26%) in the POS group. The mortality rate in the group receiving FLU prophylaxis was 17 (24%), compared to 4 (11%) in the POS group. The difference was attributed to causes other than fungal infection. Results of subgroup analysis performed for AML were similar to the general findings in terms of both incidences of fungal infection and of mortality levels. In multivariate analysis, mean duration of neutropenia was correlated with prophylaxis failure.<br>Conclusion: We conclude that both agents can be successfully used in fungal infection prophylaxis for patients at high risk for IFI. J Microbiol Infect Dis 2014;4(1): 1-6<br>


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Selçuk Kaya
Articles by Mehmet Sönmez
Articles by Iftihar Köksal
Articles by Eda Gençalioğlu
Articles by Mustafa Yılmaz
Articles by Gürdal Yılmaz
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

Selcuk Kaya, Mehmet Sonmez, Iftihar Koksal, Eda Gencalioğlu, Mustafa Yılmaz, Gurdal Yılmaz. Comparison of fluconazole and posaconazole for fungal prophylaxis in high-risk patients with hematological malignity. J Microbiol Infect Dis. 2014; 4(1): 1-6 . doi:10.5799/jmid2014.01.0115

Web Style

Selcuk Kaya, Mehmet Sonmez, Iftihar Koksal, Eda Gencalioğlu, Mustafa Yılmaz, Gurdal Yılmaz. Comparison of fluconazole and posaconazole for fungal prophylaxis in high-risk patients with hematological malignity. https://www.jmidonline.org/?mno=302657150 [Access: February 04, 2024]. doi:10.5799/jmid2014.01.0115

AMA (American Medical Association) Style

Selcuk Kaya, Mehmet Sonmez, Iftihar Koksal, Eda Gencalioğlu, Mustafa Yılmaz, Gurdal Yılmaz. Comparison of fluconazole and posaconazole for fungal prophylaxis in high-risk patients with hematological malignity. J Microbiol Infect Dis. 2014; 4(1): 1-6 . doi:10.5799/jmid2014.01.0115


Vancouver/ICMJE Style

Selcuk Kaya, Mehmet Sonmez, Iftihar Koksal, Eda Gencalioğlu, Mustafa Yılmaz, Gurdal Yılmaz. Comparison of fluconazole and posaconazole for fungal prophylaxis in high-risk patients with hematological malignity. J Microbiol Infect Dis. (2014), [cited February 04, 2024]; 4(1): 1-6 . doi:10.5799/jmid2014.01.0115


Harvard Style

Selcuk Kaya, Mehmet Sonmez, Iftihar Koksal, Eda Gencalioğlu, Mustafa Yılmaz, Gurdal Yılmaz (2014) Comparison of fluconazole and posaconazole for fungal prophylaxis in high-risk patients with hematological malignity. J Microbiol Infect Dis, 4 (1), 1-6 . doi:10.5799/jmid2014.01.0115


Turabian Style

Selcuk Kaya, Mehmet Sonmez, Iftihar Koksal, Eda Gencalioğlu, Mustafa Yılmaz, Gurdal Yılmaz. 2014. Comparison of fluconazole and posaconazole for fungal prophylaxis in high-risk patients with hematological malignity. Journal of Microbiology and Infectious Diseases, 4 (1), 1-6 . doi:10.5799/jmid2014.01.0115


Chicago Style

Selcuk Kaya, Mehmet Sonmez, Iftihar Koksal, Eda Gencalioğlu, Mustafa Yılmaz, Gurdal Yılmaz. "Comparison of fluconazole and posaconazole for fungal prophylaxis in high-risk patients with hematological malignity." Journal of Microbiology and Infectious Diseases 4 (2014), 1-6 . doi:10.5799/jmid2014.01.0115


MLA (The Modern Language Association) Style

Selcuk Kaya, Mehmet Sonmez, Iftihar Koksal, Eda Gencalioğlu, Mustafa Yılmaz, Gurdal Yılmaz. "Comparison of fluconazole and posaconazole for fungal prophylaxis in high-risk patients with hematological malignity." Journal of Microbiology and Infectious Diseases 4.1 (2014), 1-6 . Print. doi:10.5799/jmid2014.01.0115


APA (American Psychological Association) Style

Selcuk Kaya, Mehmet Sonmez, Iftihar Koksal, Eda Gencalioğlu, Mustafa Yılmaz, Gurdal Yılmaz (2014) Comparison of fluconazole and posaconazole for fungal prophylaxis in high-risk patients with hematological malignity. Journal of Microbiology and Infectious Diseases, 4 (1), 1-6 . doi:10.5799/jmid2014.01.0115


Author LoginReviewer LoginAbout PublisherOpen Access PolicyEditorial PoliciesPeer Review PolicyPublication Ethics and Publication Malpractice StatementConflict of Interest PolicyPlagiarism PolicyProtection of Research Participants (Statement On Human And Animal Rights)Privacy PolicyCorrections, Retractions & Expressions of ConcernSelf-Archiving PoliciesDigital Archiving & Preservation PoliciesStatement of Informed ConsentAdvertising PolicyTerms of UseLicense InformationCopyright Information

About Journal of Microbiology and Infectious Diseases

Journal of Microbiology and Infectious Diseases (JMID) is an international "peer review" journal in microbiology, infectious diseases, virology, ... Read more.



For best results, please use Internet Explorer or Google Chrome.

Contact Information

All correspondence should be addressed to:

Prof. Ibrahim Eldaghayes

Editor-in-Chief

Journal of Microbiology and Infectious Diseases

Department of Microbiology and Parasitology 

Faculty of Veterinary Medicine

University of Tripoli

P.O. Box 13662, Tripoli, Libya