E-ISSN 2146-9369 | ISSN 2146-3158
 

Research Article 


Abiotrophia and Granulicatella Infections in Cancer Patients: A Single-Center Chart Review Study

Joo Eun Kwon, Dae Hyun Lee, George Coba, Annie Topham, Misbahuddin Syed, Asha Ramsakal, John Greene.

Cited By:1

Abstract
Objectives: Nutritionally Variant Streptococci (NVS) comprise two primary genera that have been identified from human specimens, particularly the Abiotrophia and Granulicatella species. These infections are often complicated to manage due to the difficulty identifying these organisms, indolent course of disease, and variable resistance to common antimicrobial agents. The wide breadth of disease presentations involving these organisms has not been fully elucidated, particularly in the immunosuppressed cancer patient population.<br>Method: We performed a retrospective chart review on 28 patients from an academic cancer center with positive NVS cultures, from January 2012 to July 2018. We reviewed patient characteristics, culture data, immunodeficiency status, response to antibiotic therapy, and outcomes of infection.<br>Results: Of twenty-eight patients, fifteen patients developed bacteremia from either Abiotrophia or Granulicatella species, while thirteen patients had positive wound or body fluid cultures. Most patients with bacteremia had underlying hematologic malignancies and neutropenia. Patients with positive wound or body fluid cultures had an invasive procedure at the related site. Intravenous (IV) vancomycin was the most common agent used, and all but two patients were treated with multiple antibiotic regimens.<br>Conclusions: Infections with NVS have been reported with a variety of clinically infectious presentations and should be considered in cancer patients with neutropenia or in patients who have undergone invasive procedures. Bacteremia was the most common complication, especially in the setting of hematologic malignancy and neutropenia. Focal body site infection was also a common complication related to invasive procedures in immunocompetent patients. Overall mortality was low and related to complications of septic shock. J Microbiol Infect Dis 2020; 10(2):89-97.

Key words: Abiotrophia, Granulicatella, bacteremia, cancer, neutropenic infection


 
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How to Cite this Article
Pubmed Style

Joo Eun Kwon, Dae Hyun Lee, George Coba, Annie Topham, Misbahuddin Syed, Asha Ramsakal, John Greene. Abiotrophia and Granulicatella Infections in Cancer Patients: A Single-Center Chart Review Study. J Microbiol Infect Dis. 2020; 10(2): 89-97 . doi:10.5799/jmid.748711


Web Style

Joo Eun Kwon, Dae Hyun Lee, George Coba, Annie Topham, Misbahuddin Syed, Asha Ramsakal, John Greene. Abiotrophia and Granulicatella Infections in Cancer Patients: A Single-Center Chart Review Study. https://www.jmidonline.org/?mno=302657065 [Access: February 04, 2024]. doi:10.5799/jmid.748711


AMA (American Medical Association) Style

Joo Eun Kwon, Dae Hyun Lee, George Coba, Annie Topham, Misbahuddin Syed, Asha Ramsakal, John Greene. Abiotrophia and Granulicatella Infections in Cancer Patients: A Single-Center Chart Review Study. J Microbiol Infect Dis. 2020; 10(2): 89-97 . doi:10.5799/jmid.748711



Vancouver/ICMJE Style

Joo Eun Kwon, Dae Hyun Lee, George Coba, Annie Topham, Misbahuddin Syed, Asha Ramsakal, John Greene. Abiotrophia and Granulicatella Infections in Cancer Patients: A Single-Center Chart Review Study. J Microbiol Infect Dis. (2020), [cited February 04, 2024]; 10(2): 89-97 . doi:10.5799/jmid.748711



Harvard Style

Joo Eun Kwon, Dae Hyun Lee, George Coba, Annie Topham, Misbahuddin Syed, Asha Ramsakal, John Greene (2020) Abiotrophia and Granulicatella Infections in Cancer Patients: A Single-Center Chart Review Study. J Microbiol Infect Dis, 10 (2), 89-97 . doi:10.5799/jmid.748711



Turabian Style

Joo Eun Kwon, Dae Hyun Lee, George Coba, Annie Topham, Misbahuddin Syed, Asha Ramsakal, John Greene. 2020. Abiotrophia and Granulicatella Infections in Cancer Patients: A Single-Center Chart Review Study. Journal of Microbiology and Infectious Diseases, 10 (2), 89-97 . doi:10.5799/jmid.748711



Chicago Style

Joo Eun Kwon, Dae Hyun Lee, George Coba, Annie Topham, Misbahuddin Syed, Asha Ramsakal, John Greene. "Abiotrophia and Granulicatella Infections in Cancer Patients: A Single-Center Chart Review Study." Journal of Microbiology and Infectious Diseases 10 (2020), 89-97 . doi:10.5799/jmid.748711



MLA (The Modern Language Association) Style

Joo Eun Kwon, Dae Hyun Lee, George Coba, Annie Topham, Misbahuddin Syed, Asha Ramsakal, John Greene. "Abiotrophia and Granulicatella Infections in Cancer Patients: A Single-Center Chart Review Study." Journal of Microbiology and Infectious Diseases 10.2 (2020), 89-97 . Print. doi:10.5799/jmid.748711



APA (American Psychological Association) Style

Joo Eun Kwon, Dae Hyun Lee, George Coba, Annie Topham, Misbahuddin Syed, Asha Ramsakal, John Greene (2020) Abiotrophia and Granulicatella Infections in Cancer Patients: A Single-Center Chart Review Study. Journal of Microbiology and Infectious Diseases, 10 (2), 89-97 . doi:10.5799/jmid.748711