E-ISSN 2146-9369 | ISSN 2146-3158
 
2024, Vol: 14, Issue: 1
14 / 1Current Issue ArchiveAims and ScopeAbstracting & IndexingMost Accessed ArticlesMost Downloaded ArticlesMost Cited Articles

Research Article 


Evaluation of immune status against hepatitis B in children with thalassemia major in Egypt: A single center study

Hanan H. Soliman, Ibrahim Kabbash A., Mohamed R. El-Shanshory, Hala M. Nagy, Said H. Abdou.


Cited By:11

Abstract
Objectives: Thalassemic children with repeated blood transfusion are at higher risk of suffering transfusion related infections including hepatitis B virus (HBV). HBV vaccine immunogenicity in several studies showed variable response rates. The aim of this study is to evaluate the immunogenic effect of hepatitis B vaccine in thalassemic children at different age groups.<br>Materials and methods: After ethical approval and informed parent consent, 125 diagnosed thalassemic patients were recruited from the Hematology/Oncology Unit, Pediatric Department, Tanta University Hospital. Patient 's transfusion, and vaccination history, clinical data, and blood samples were obtained. Patient 's sera were stored at -20°C till tested for Anti-hepatitis B surface (anti-HBs) by ELISA. Patients with titers <10 IU were tested for HBs-Ag.<br>Results: Although none of our cases had hepatitis B virus infection, only 20.8% had a protective anti-HBs titer (>10 IU/L). Significantly higher percentage of protected patients (40.1%) were younger than 3 years of age, while age groups above 3years showed a significant trend towards having non protective titers (p=0.003). Anti-HBs titers weren 't correlated to age, ferritin, liver enzymes, and duration of transfusion or number of transfused packs.<br>Conclusion: Protective Anti-HBs titer was reduced after age of 3 years in our patients. So, we recommend screening of thalassemic patients at age of 3 years to evaluate the need of a booster dose. J Microbiol Infect Dis 2012; 2(2): 44-49

Key words: Thalassemia, HBV, vaccination, immunogenicity


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Hanan H. Soliman
Articles by Ibrahim Kabbash A.
Articles by Mohamed R. El-Shanshory
Articles by Hala M. Nagy
Articles by Said H. Abdou
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

Hanan H. Soliman, Ibrahim Kabbash A., Mohamed R. El-Shanshory, Hala M. Nagy, Said H. Abdou. Evaluation of immune status against hepatitis B in children with thalassemia major in Egypt: A single center study. J Microbiol Infect Dis. 2012; 2(2): 44-49 . doi:10.5799/jmid2012.03.0041

Web Style

Hanan H. Soliman, Ibrahim Kabbash A., Mohamed R. El-Shanshory, Hala M. Nagy, Said H. Abdou. Evaluation of immune status against hepatitis B in children with thalassemia major in Egypt: A single center study. https://www.jmidonline.org/?mno=302657049 [Access: April 26, 2024]. doi:10.5799/jmid2012.03.0041

AMA (American Medical Association) Style

Hanan H. Soliman, Ibrahim Kabbash A., Mohamed R. El-Shanshory, Hala M. Nagy, Said H. Abdou. Evaluation of immune status against hepatitis B in children with thalassemia major in Egypt: A single center study. J Microbiol Infect Dis. 2012; 2(2): 44-49 . doi:10.5799/jmid2012.03.0041


Vancouver/ICMJE Style

Hanan H. Soliman, Ibrahim Kabbash A., Mohamed R. El-Shanshory, Hala M. Nagy, Said H. Abdou. Evaluation of immune status against hepatitis B in children with thalassemia major in Egypt: A single center study. J Microbiol Infect Dis. (2012), [cited April 26, 2024]; 2(2): 44-49 . doi:10.5799/jmid2012.03.0041


Harvard Style

Hanan H. Soliman, Ibrahim Kabbash A., Mohamed R. El-Shanshory, Hala M. Nagy, Said H. Abdou (2012) Evaluation of immune status against hepatitis B in children with thalassemia major in Egypt: A single center study. J Microbiol Infect Dis, 2 (2), 44-49 . doi:10.5799/jmid2012.03.0041


Turabian Style

Hanan H. Soliman, Ibrahim Kabbash A., Mohamed R. El-Shanshory, Hala M. Nagy, Said H. Abdou. 2012. Evaluation of immune status against hepatitis B in children with thalassemia major in Egypt: A single center study. Journal of Microbiology and Infectious Diseases, 2 (2), 44-49 . doi:10.5799/jmid2012.03.0041


Chicago Style

Hanan H. Soliman, Ibrahim Kabbash A., Mohamed R. El-Shanshory, Hala M. Nagy, Said H. Abdou. "Evaluation of immune status against hepatitis B in children with thalassemia major in Egypt: A single center study." Journal of Microbiology and Infectious Diseases 2 (2012), 44-49 . doi:10.5799/jmid2012.03.0041


MLA (The Modern Language Association) Style

Hanan H. Soliman, Ibrahim Kabbash A., Mohamed R. El-Shanshory, Hala M. Nagy, Said H. Abdou. "Evaluation of immune status against hepatitis B in children with thalassemia major in Egypt: A single center study." Journal of Microbiology and Infectious Diseases 2.2 (2012), 44-49 . Print. doi:10.5799/jmid2012.03.0041


APA (American Psychological Association) Style

Hanan H. Soliman, Ibrahim Kabbash A., Mohamed R. El-Shanshory, Hala M. Nagy, Said H. Abdou (2012) Evaluation of immune status against hepatitis B in children with thalassemia major in Egypt: A single center study. Journal of Microbiology and Infectious Diseases, 2 (2), 44-49 . doi:10.5799/jmid2012.03.0041


Author LoginReviewer LoginAbout PublisherOpen Access PolicyEditorial PoliciesPeer Review PolicyPublication Ethics and Publication Malpractice StatementConflict of Interest PolicyPlagiarism PolicyProtection of Research Participants (Statement On Human And Animal Rights)Privacy PolicyCorrections, Retractions & Expressions of ConcernSelf-Archiving PoliciesDigital Archiving & Preservation PoliciesStatement of Informed ConsentAdvertising PolicyTerms of UseLicense InformationCopyright Information

About Journal of Microbiology and Infectious Diseases

Journal of Microbiology and Infectious Diseases (JMID) is an international "peer review" journal in microbiology, infectious diseases, virology, ... Read more.



For best results, please use Internet Explorer or Google Chrome.

Contact Information

All correspondence should be addressed to:

Prof. Ibrahim Eldaghayes

Editor-in-Chief

Journal of Microbiology and Infectious Diseases

Department of Microbiology and Parasitology 

Faculty of Veterinary Medicine

University of Tripoli

P.O. Box 13662, Tripoli, Libya