E-ISSN 2146-9369 | ISSN 2146-3158
 

Research Article 


Evaluation of Biomarkers and Severity of COVID-19 in A Single Center

Demet Yalcın, Seyda Ignak, Isılsu Ezgi Uluısık, Olida Cecen, Muhammed Mert Sonkaya, Ozlem Unay-Demirel.

Abstract
Objectives: The clinical course of COVID-19 ranges from mild to severe. The predictability of clinical outcomes gains importance in managing the disease. In this retrospective cohort study, we aimed to investigate the relationship between biomarker levels and the clinical severity of COVID-19.<br>Methods: COVID-19 patients (n=618) admitted to a tertiary care hospital in Istanbul, Turkey were classified according to their clinical status using a scoring system designed by WHO. Laboratory parameters such as D-dimer, ferritin, and lymphocyte count levels were evaluated. In order to find out the relation between laboratory biomarkers and the severity of COVID-19, univariable and multivariable logistic regression analyses were used.<br>Results: A positive correlation was found when WHO Score was compared with D-dimer levels (r=.508, p<0.01), and ferritin levels (r=.391, p<0.01), whereas a negative correlation was observed between WHO Score and lymphocyte count levels (r=-.381, p<0.01). The cut-off values for D-dimer and ferritin were found as 0.86 ng/mL (70.9% sensitivity and 87.1% specificity) and 92.74 ng/mL (78.5% sensitivity and 52.2% specificity) respectively. According to the multivariable logistic regression model, lymphocyte count (β=- 0.305, p<0.001) and D-dimer levels (β=1.326, p<0.001) are the statistically significant regressors for hospitalization need.<br>Conclusion: Patients with higher D-dimer and ferritin levels were likely to have more severe disease, whereas patients with higher lymphocyte counts overcame the disease mildly. Unlike other studies, evaluating D-dimer and lymphocyte count will likely give more detailed information on COVID-19 clinical outcomes. J Microbiol Infect Dis 2022; 12(3):89-96.

Key words: COVID-19, ferritin; D-dimer, absolute lymphocyte count, multivariable logistic regression analysis


 
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How to Cite this Article
Pubmed Style

Demet Yalcın, Seyda Ignak, Isılsu Ezgi Uluısık, Olida Cecen, Muhammed Mert Sonkaya, Ozlem Unay-Demirel. Evaluation of Biomarkers and Severity of COVID-19 in A Single Center. J Microbiol Infect Dis. 2022; 12(3): 89-96 . doi:10.5799/jmid.1175432


Web Style

Demet Yalcın, Seyda Ignak, Isılsu Ezgi Uluısık, Olida Cecen, Muhammed Mert Sonkaya, Ozlem Unay-Demirel. Evaluation of Biomarkers and Severity of COVID-19 in A Single Center. https://www.jmidonline.org/?mno=302657008 [Access: February 03, 2024]. doi:10.5799/jmid.1175432


AMA (American Medical Association) Style

Demet Yalcın, Seyda Ignak, Isılsu Ezgi Uluısık, Olida Cecen, Muhammed Mert Sonkaya, Ozlem Unay-Demirel. Evaluation of Biomarkers and Severity of COVID-19 in A Single Center. J Microbiol Infect Dis. 2022; 12(3): 89-96 . doi:10.5799/jmid.1175432



Vancouver/ICMJE Style

Demet Yalcın, Seyda Ignak, Isılsu Ezgi Uluısık, Olida Cecen, Muhammed Mert Sonkaya, Ozlem Unay-Demirel. Evaluation of Biomarkers and Severity of COVID-19 in A Single Center. J Microbiol Infect Dis. (2022), [cited February 03, 2024]; 12(3): 89-96 . doi:10.5799/jmid.1175432



Harvard Style

Demet Yalcın, Seyda Ignak, Isılsu Ezgi Uluısık, Olida Cecen, Muhammed Mert Sonkaya, Ozlem Unay-Demirel (2022) Evaluation of Biomarkers and Severity of COVID-19 in A Single Center. J Microbiol Infect Dis, 12 (3), 89-96 . doi:10.5799/jmid.1175432



Turabian Style

Demet Yalcın, Seyda Ignak, Isılsu Ezgi Uluısık, Olida Cecen, Muhammed Mert Sonkaya, Ozlem Unay-Demirel. 2022. Evaluation of Biomarkers and Severity of COVID-19 in A Single Center. Journal of Microbiology and Infectious Diseases, 12 (3), 89-96 . doi:10.5799/jmid.1175432



Chicago Style

Demet Yalcın, Seyda Ignak, Isılsu Ezgi Uluısık, Olida Cecen, Muhammed Mert Sonkaya, Ozlem Unay-Demirel. "Evaluation of Biomarkers and Severity of COVID-19 in A Single Center." Journal of Microbiology and Infectious Diseases 12 (2022), 89-96 . doi:10.5799/jmid.1175432



MLA (The Modern Language Association) Style

Demet Yalcın, Seyda Ignak, Isılsu Ezgi Uluısık, Olida Cecen, Muhammed Mert Sonkaya, Ozlem Unay-Demirel. "Evaluation of Biomarkers and Severity of COVID-19 in A Single Center." Journal of Microbiology and Infectious Diseases 12.3 (2022), 89-96 . Print. doi:10.5799/jmid.1175432



APA (American Psychological Association) Style

Demet Yalcın, Seyda Ignak, Isılsu Ezgi Uluısık, Olida Cecen, Muhammed Mert Sonkaya, Ozlem Unay-Demirel (2022) Evaluation of Biomarkers and Severity of COVID-19 in A Single Center. Journal of Microbiology and Infectious Diseases, 12 (3), 89-96 . doi:10.5799/jmid.1175432