Abstract
Objective: Crimean-Congo hemorrhagic fever (CCHF) virus, a Nairovirus within the family Bunyaviridae, causes severe disease in humans. Pancytopenia, organ failures and disseminated intravascular coagulation may occur as a result of CCHF infection. The aim of this study was to determine whether there is a change in the mean platelet volume (MPV), neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR), and whether these might be predictors for the duration of hospitalization.<br>Methods: A total of 50 CCHF patients (27 M and 23 F) and a similar age group of 47 healthy individuals (27 M and 20 F) were included in the study. Hematologic and biochemical tests inclusive of C-reactive protein were conducted on patients and controls. To determine the independent predictors of the duration of hospitalization, a multivariate logistic regression analysis was performed.<br>Results: The MPV was higher in patients than that of the controls [8.4 (min/max 6.4-9.4) fL vs. 7.0 (min/max 6.0-8.7) fL, p<0.001]. The NLR and PLR were similar in both groups. The predictors of the length of hospitalization included decreased white blood (WBC) cell and platelet counts (p<0.001 and p=0.002, respectively), together with elevated pro¬thrombin time (PT) (p=0.013) creatinine (p=0.033) and glucose levels (p=0.044).<br>Conclusion: The MPV was higher in patients but NLR and PLR were similar in both groups. The MPV, NLR and PLR did not serve as predictors of hospitalization length. However, elevation of PT, creatinine, glucose, along with decreased WBC and platelets counts were found to be predictors of hospitalization period. J Microbiol Infect Dis 2015;5(2): 51-56<br>Ayşe Ertürk, Erkan Cüre, Emine Parlak, Medine Cumhur Cüre, Süleyman Yüce, Zulal Özkurt<br>Prognostic value of mean platelet volume and neutrophil to lymphocyte ratio in patients with Crimean-Congo Hemorrhagic Fever Ayşe Ertürk, Erkan Cüre, Emine Parlak, Medine Cumhur Cüre, Süleyman Yüce, Zulal Özkurt Recep Tayyip Erdogan University, School of Medicine, Department of Infectious Disease, Rize, Turkey. J Microbiol Infect Dis 2015; 5(2): 51-56 doi: 10.5799/ahinjs.02.2015.02.0176