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2024, Vol: 14, Issue: 1
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Research Article 


Predictive values of serum amyloid-A (SAA) and C-reactive protein (CRP) for infection in febrile neutropenic cancer patients

Ayse Batirel, Serap Gençer, Serdar Özer, Taflan Salepçi.

Abstract
Objectives: To evaluate predictive values of serum amyloid A (SAA) and C-reactive protein (CRP) for infection and mor¬tality in patients with febrile neutropenia (FEN).<br>Methods: Daily measurement of serum SAA and CRP levels of patients during antibiotherapy for FEN.<br>Results: Sixty-five FEN episodes of 52 patients were evaluated. Median CRP and SAA levels on 1st day of FEN were 137 mg/L (23-420 mg/L) and 547 mg/L (11-1660 mg/L), respectively. For detection of infection of infection the sensitivity, positive predictive value (PPV), and negative predictive value (NPV) of SAA at a level of >80 mg/L were as 100%, 48% and 100%. Whilethe sensitivity, PPV, and NPV of CRP at a level of >50mg/L were as 86%, 47% and 60%, respectively. Predictive values of initial SAA and CRP levels for infection didn 't differ significantly (CRP: p=0.24, SAA: p=0.39). SAA and CRP levels on the last day of FEN course were significant for infection and mortality (for infection: p=0.003 for CRP and p=0.026 for SAA; for mortality: p<0.001 for CRP and p=0.021 for SAA). Both initial and daily SAA and CRP levels correlated with each other positively and statistically significantly (p<0.001). The area under the curve (AUC) on the re¬ceiver operating character (ROC) curve for CRP and SAA were 0.72 (p=0.003, 95% CI: 0.59-0.86) and 0.68 (p=0.19, 95% CI: 0.54-0.82), respectively.<br>Conclusions: Despite low predictive values in decision of initial therapy, these parameters would be helpful in decision of modification and evaluation of response to therapy. J Microbiol Infect Dis 2014; 4(4): 128-135

Key words: Fever, neutropenia, febrile neutropenia, C-reactive protein, serum amyloid A Ayşe Batırel, Serap Gencer, Serdar Özer, Taflan Salepci. Evaluation of predictive values of serum amyloid-A (SAA) and C-reactive protein (CRP) for infection in febrile neutropenic cancer patients. J Microbiol Infect Dis 2014; 4(4): 128-135 doi: 10.5799/ahinjs.02.2014.04.0155


 
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How to Cite this Article
Pubmed Style

Ayse Batirel, Serap Gencer, Serdar Ozer, Taflan Salepci. Predictive values of serum amyloid-A (SAA) and C-reactive protein (CRP) for infection in febrile neutropenic cancer patients. J Microbiol Infect Dis. 2014; 4(4): 128-135 . doi:10.5799/jmid2014.04.0155

Web Style

Ayse Batirel, Serap Gencer, Serdar Ozer, Taflan Salepci. Predictive values of serum amyloid-A (SAA) and C-reactive protein (CRP) for infection in febrile neutropenic cancer patients. https://www.jmidonline.org/?mno=302656980 [Access: February 03, 2024]. doi:10.5799/jmid2014.04.0155

AMA (American Medical Association) Style

Ayse Batirel, Serap Gencer, Serdar Ozer, Taflan Salepci. Predictive values of serum amyloid-A (SAA) and C-reactive protein (CRP) for infection in febrile neutropenic cancer patients. J Microbiol Infect Dis. 2014; 4(4): 128-135 . doi:10.5799/jmid2014.04.0155


Vancouver/ICMJE Style

Ayse Batirel, Serap Gencer, Serdar Ozer, Taflan Salepci. Predictive values of serum amyloid-A (SAA) and C-reactive protein (CRP) for infection in febrile neutropenic cancer patients. J Microbiol Infect Dis. (2014), [cited February 03, 2024]; 4(4): 128-135 . doi:10.5799/jmid2014.04.0155


Harvard Style

Ayse Batirel, Serap Gencer, Serdar Ozer, Taflan Salepci (2014) Predictive values of serum amyloid-A (SAA) and C-reactive protein (CRP) for infection in febrile neutropenic cancer patients. J Microbiol Infect Dis, 4 (4), 128-135 . doi:10.5799/jmid2014.04.0155


Turabian Style

Ayse Batirel, Serap Gencer, Serdar Ozer, Taflan Salepci. 2014. Predictive values of serum amyloid-A (SAA) and C-reactive protein (CRP) for infection in febrile neutropenic cancer patients. Journal of Microbiology and Infectious Diseases, 4 (4), 128-135 . doi:10.5799/jmid2014.04.0155


Chicago Style

Ayse Batirel, Serap Gencer, Serdar Ozer, Taflan Salepci. "Predictive values of serum amyloid-A (SAA) and C-reactive protein (CRP) for infection in febrile neutropenic cancer patients." Journal of Microbiology and Infectious Diseases 4 (2014), 128-135 . doi:10.5799/jmid2014.04.0155


MLA (The Modern Language Association) Style

Ayse Batirel, Serap Gencer, Serdar Ozer, Taflan Salepci. "Predictive values of serum amyloid-A (SAA) and C-reactive protein (CRP) for infection in febrile neutropenic cancer patients." Journal of Microbiology and Infectious Diseases 4.4 (2014), 128-135 . Print. doi:10.5799/jmid2014.04.0155


APA (American Psychological Association) Style

Ayse Batirel, Serap Gencer, Serdar Ozer, Taflan Salepci (2014) Predictive values of serum amyloid-A (SAA) and C-reactive protein (CRP) for infection in febrile neutropenic cancer patients. Journal of Microbiology and Infectious Diseases, 4 (4), 128-135 . doi:10.5799/jmid2014.04.0155


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