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2024, Vol: 14, Issue: 1
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Research Article 


Evaluation of diagnostic tests for visceral leishmaniasis in Iran: a systematic review and meta-analysis

Assad Mirzaei, azar najafi, Entezar Abbasi Somar, Kourosh Sayehmiri, Hamidreza Majidiani.

Abstract
Objective: There exist various diagnostic tests to detect visceral leishmaniasis, but the most efficient ones have not been demonstrated yet. Herein, we evaluated the accuracy of these diagnostic tests in Iran.<br>Methodology: English and Persian database searching was done from 1993 to 2016. According to heterogeneity of the studies, estimations of the study were pooled by random-effects model. Totally, twenty investigations were eligible for current review with 2115 patients as pooled sample size.<br>Results: The overall pooled estimate of sensitivity and specificity for all diagnostic tests were 0.92 ([95% CI = 0.90–0.95]) and 0.92 ([95% CI = 0.89–0.94]), respectively. Also, the separate sensitivity and specificity of each test were as follow: PCR: 1.00 ([95% CI = 0.99–1.01]) and 0.37 ([95% CI = 0.25–0.49]); DAT: 0.93 ([95% CI = 0.89–0.96]) and 0.92 ([95% CI = 0.89–0.94]); ELISA: 0.78 ([95% CI = 0.47–1.09]) and 1.00 ([95% CI = 0.99–1.01]) as well as IFA: 0.50 ([95% CI = 0.29–0.72]) and 0.96 ([95% CI = 0.95–0.97]).<br>Conclusions: The specificity and sensitivity of PCR and DAT as molecular and serological tests, respectively, are remarkable to detect visceral leishmaniasis; hence, it is highly recommended to simultaneously employ these diagnostic tests for this widespread infection. J Microbiol Infect Dis 2019; 9(1): 16-22.

Key words: Visceral Leishmaniasis, sensitivity, specificity, diagnostic tests, L. infantum, Iran


 
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How to Cite this Article
Pubmed Style

Assad Mirzaei, azar najafi, Entezar Abbasi Somar, Kourosh Sayehmiri, Hamidreza Majidiani. Evaluation of diagnostic tests for visceral leishmaniasis in Iran: a systematic review and meta-analysis. J Microbiol Infect Dis. 2019; 9(1): 16-22 . doi:10.5799/jmid.537150

Web Style

Assad Mirzaei, azar najafi, Entezar Abbasi Somar, Kourosh Sayehmiri, Hamidreza Majidiani. Evaluation of diagnostic tests for visceral leishmaniasis in Iran: a systematic review and meta-analysis. https://www.jmidonline.org/?mno=302656974 [Access: February 03, 2024]. doi:10.5799/jmid.537150

AMA (American Medical Association) Style

Assad Mirzaei, azar najafi, Entezar Abbasi Somar, Kourosh Sayehmiri, Hamidreza Majidiani. Evaluation of diagnostic tests for visceral leishmaniasis in Iran: a systematic review and meta-analysis. J Microbiol Infect Dis. 2019; 9(1): 16-22 . doi:10.5799/jmid.537150


Vancouver/ICMJE Style

Assad Mirzaei, azar najafi, Entezar Abbasi Somar, Kourosh Sayehmiri, Hamidreza Majidiani. Evaluation of diagnostic tests for visceral leishmaniasis in Iran: a systematic review and meta-analysis. J Microbiol Infect Dis. (2019), [cited February 03, 2024]; 9(1): 16-22 . doi:10.5799/jmid.537150


Harvard Style

Assad Mirzaei, azar najafi, Entezar Abbasi Somar, Kourosh Sayehmiri, Hamidreza Majidiani (2019) Evaluation of diagnostic tests for visceral leishmaniasis in Iran: a systematic review and meta-analysis. J Microbiol Infect Dis, 9 (1), 16-22 . doi:10.5799/jmid.537150


Turabian Style

Assad Mirzaei, azar najafi, Entezar Abbasi Somar, Kourosh Sayehmiri, Hamidreza Majidiani. 2019. Evaluation of diagnostic tests for visceral leishmaniasis in Iran: a systematic review and meta-analysis. Journal of Microbiology and Infectious Diseases, 9 (1), 16-22 . doi:10.5799/jmid.537150


Chicago Style

Assad Mirzaei, azar najafi, Entezar Abbasi Somar, Kourosh Sayehmiri, Hamidreza Majidiani. "Evaluation of diagnostic tests for visceral leishmaniasis in Iran: a systematic review and meta-analysis." Journal of Microbiology and Infectious Diseases 9 (2019), 16-22 . doi:10.5799/jmid.537150


MLA (The Modern Language Association) Style

Assad Mirzaei, azar najafi, Entezar Abbasi Somar, Kourosh Sayehmiri, Hamidreza Majidiani. "Evaluation of diagnostic tests for visceral leishmaniasis in Iran: a systematic review and meta-analysis." Journal of Microbiology and Infectious Diseases 9.1 (2019), 16-22 . Print. doi:10.5799/jmid.537150


APA (American Psychological Association) Style

Assad Mirzaei, azar najafi, Entezar Abbasi Somar, Kourosh Sayehmiri, Hamidreza Majidiani (2019) Evaluation of diagnostic tests for visceral leishmaniasis in Iran: a systematic review and meta-analysis. Journal of Microbiology and Infectious Diseases, 9 (1), 16-22 . doi:10.5799/jmid.537150


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