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2024, Vol: 14, Issue: 1
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Research Article 


Resistance patterns and trends of extensively drug-resistant tuberculosis: 5-year experience

Amresh Kumar Singh, Anand Kumar Maurya, Manoj Kumar, Surya Kant, Ram Awadh Singh Kushwaha, Vijaya Lakshmi Nag, Tapan N Dhole.

Cited By:2

Abstract
Objective: Extensively drug-resistant tuberculosis (XDR-TB) strains were emerged when multidrug-resistant TB (MDR-TB) was inadequately treated. Inadequate treatment of MDR-TB cases may result in additional resistance especially non-XDR-TB and then XDR-TB. The aim of this study was to know the prevalence, resistance patterns and trends of the XDR-TB strains among the MDR-TB at a tertiary care hospital in Lucknow, India<br>Methods: A total of 430 Mycobacterium isolates were underwent NAP test and TB MPT64 Ag test for the identification of Mycobacterium tuberculosis complex (MTBC). Drug-susceptibility test (DST) was performed over MTBC for the first line drugs by 1% proportion method (Bactec) and for the second-line drugs by 1% proportion method (Lowenstein-Jensen media). The XDR-TB status was further confirmed by line probe assay (GenoType® MTBDRsl assay).<br>Results: Among the 430 isolates of mycobacterium, 365 (84.9%) were MTBC and 139 (38.1%) were MDR-TB respectively. Further 97 MDR-TB from ”highly suspected drug resistant-TB (DR-TB)” cases among MDR-TB were tested with second line drugs in which 15 (15.5%) XDR-TB and 82 (84.5%) were non-XDR-TB. Regarding XDR-TB status, using the 1% proportion method a 100% agreement was seen with the GenoType® MTBDRsl assay. Resistance patterns of XDR-TB were as; 10/15 (66.7%) as isoniazid + rifampicin + ciprofloxacin + amikacin resistance and 5/15 (33.3%) as isoniazid + rifampicin + ciprofloxacin + amikacin + kanamycin resistance.<br>Conclusion: The prevalence of XDR-TB was 15.5% among MDR-TB. Hence laboratory testing of ”highly suspected drug resistant-TB” isolates should be done for both first and second line drugs simultaneously especially in developing countries. J Microbiol Infect Dis 2013; 3(4): 87-90


 
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How to Cite this Article
Pubmed Style

Amresh Kumar Singh, Anand Kumar Maurya, Manoj Kumar, Surya Kant, Ram Awadh Singh Kushwaha, Vijaya Lakshmi Nag, Tapan N Dhole. Resistance patterns and trends of extensively drug-resistant tuberculosis: 5-year experience. J Microbiol Infect Dis. 2013; 3(4): 169-175 . doi:10.5799/jmid2013.04.0103

Web Style

Amresh Kumar Singh, Anand Kumar Maurya, Manoj Kumar, Surya Kant, Ram Awadh Singh Kushwaha, Vijaya Lakshmi Nag, Tapan N Dhole. Resistance patterns and trends of extensively drug-resistant tuberculosis: 5-year experience. https://www.jmidonline.org/?mno=302656964 [Access: February 03, 2024]. doi:10.5799/jmid2013.04.0103

AMA (American Medical Association) Style

Amresh Kumar Singh, Anand Kumar Maurya, Manoj Kumar, Surya Kant, Ram Awadh Singh Kushwaha, Vijaya Lakshmi Nag, Tapan N Dhole. Resistance patterns and trends of extensively drug-resistant tuberculosis: 5-year experience. J Microbiol Infect Dis. 2013; 3(4): 169-175 . doi:10.5799/jmid2013.04.0103


Vancouver/ICMJE Style

Amresh Kumar Singh, Anand Kumar Maurya, Manoj Kumar, Surya Kant, Ram Awadh Singh Kushwaha, Vijaya Lakshmi Nag, Tapan N Dhole. Resistance patterns and trends of extensively drug-resistant tuberculosis: 5-year experience. J Microbiol Infect Dis. (2013), [cited February 03, 2024]; 3(4): 169-175 . doi:10.5799/jmid2013.04.0103


Harvard Style

Amresh Kumar Singh, Anand Kumar Maurya, Manoj Kumar, Surya Kant, Ram Awadh Singh Kushwaha, Vijaya Lakshmi Nag, Tapan N Dhole (2013) Resistance patterns and trends of extensively drug-resistant tuberculosis: 5-year experience. J Microbiol Infect Dis, 3 (4), 169-175 . doi:10.5799/jmid2013.04.0103


Turabian Style

Amresh Kumar Singh, Anand Kumar Maurya, Manoj Kumar, Surya Kant, Ram Awadh Singh Kushwaha, Vijaya Lakshmi Nag, Tapan N Dhole. 2013. Resistance patterns and trends of extensively drug-resistant tuberculosis: 5-year experience. Journal of Microbiology and Infectious Diseases, 3 (4), 169-175 . doi:10.5799/jmid2013.04.0103


Chicago Style

Amresh Kumar Singh, Anand Kumar Maurya, Manoj Kumar, Surya Kant, Ram Awadh Singh Kushwaha, Vijaya Lakshmi Nag, Tapan N Dhole. "Resistance patterns and trends of extensively drug-resistant tuberculosis: 5-year experience." Journal of Microbiology and Infectious Diseases 3 (2013), 169-175 . doi:10.5799/jmid2013.04.0103


MLA (The Modern Language Association) Style

Amresh Kumar Singh, Anand Kumar Maurya, Manoj Kumar, Surya Kant, Ram Awadh Singh Kushwaha, Vijaya Lakshmi Nag, Tapan N Dhole. "Resistance patterns and trends of extensively drug-resistant tuberculosis: 5-year experience." Journal of Microbiology and Infectious Diseases 3.4 (2013), 169-175 . Print. doi:10.5799/jmid2013.04.0103


APA (American Psychological Association) Style

Amresh Kumar Singh, Anand Kumar Maurya, Manoj Kumar, Surya Kant, Ram Awadh Singh Kushwaha, Vijaya Lakshmi Nag, Tapan N Dhole (2013) Resistance patterns and trends of extensively drug-resistant tuberculosis: 5-year experience. Journal of Microbiology and Infectious Diseases, 3 (4), 169-175 . doi:10.5799/jmid2013.04.0103


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