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2024, Vol: 14, Issue: 1
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Research Article 


In-vitro Activity of Tigecycline against Methicillin-Resistant Staphylococcus aureus Isolated from Wounds of Burn Patients in Tripoli-Libya

Abdulazziz Zorgani, Omar Elahmer, Hisham Ziglam, Khalifa Sifaw Ghenghesh.

Abstract
Objectives: Tigecycline is a new glycylcycline group antibiotic with broad-spectrum activity. In the present study we report on in vitro activity of tigecycline as well as the comparator antimicrobials linezolid and quinupristin/dalfopristin against methicillin-susceptible Staphylococcus aureus (MSSA) and methicillin resistant Staphylococcus aureus (MRSA) strains isolated from burn wounds in Tripoli-Libya.<br>Materials and methods: Included in the study 155 MSSA and 144 MRSA isolates from wounds of burn patients and identiied by PCR. The susceptibility of MSSA and MRSA isolates to tigecycline, linezolid and quinupristin/dalfopristin was determined by the disc diffusion technique.<br>Results: Of the MSSA and MRSA isolates examined, susceptibility to tigecycline was observed in 96.8% and 95.8%, to linezolid in 97.4% and 96.5% and to quinupristin/dalfopristin in 98.1% and 97.2%, respectively.<br>Conclusion: Tigecycline showed excellent in-vitro activity against MSSA and MRSA similar to the comparator drugs (i.e. linezolid and quinupristin/dalfopristin). However, tigecycline should be used to treat serious infections when no other option exists. J Microbiol Infect Dis 2012; 2(3): 109-112


 
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How to Cite this Article
Pubmed Style

Abdulazziz Zorgani, Omar Elahmer, Hisham Ziglam, Khalifa Sifaw Ghenghesh. In-vitro Activity of Tigecycline against Methicillin-Resistant Staphylococcus aureus Isolated from Wounds of Burn Patients in Tripoli-Libya. J Microbiol Infect Dis. 2012; 2(3): 109-112 . doi:10.5799/jmid2012.03.0053

Web Style

Abdulazziz Zorgani, Omar Elahmer, Hisham Ziglam, Khalifa Sifaw Ghenghesh. In-vitro Activity of Tigecycline against Methicillin-Resistant Staphylococcus aureus Isolated from Wounds of Burn Patients in Tripoli-Libya. https://www.jmidonline.org/?mno=302656947 [Access: February 03, 2024]. doi:10.5799/jmid2012.03.0053

AMA (American Medical Association) Style

Abdulazziz Zorgani, Omar Elahmer, Hisham Ziglam, Khalifa Sifaw Ghenghesh. In-vitro Activity of Tigecycline against Methicillin-Resistant Staphylococcus aureus Isolated from Wounds of Burn Patients in Tripoli-Libya. J Microbiol Infect Dis. 2012; 2(3): 109-112 . doi:10.5799/jmid2012.03.0053


Vancouver/ICMJE Style

Abdulazziz Zorgani, Omar Elahmer, Hisham Ziglam, Khalifa Sifaw Ghenghesh. In-vitro Activity of Tigecycline against Methicillin-Resistant Staphylococcus aureus Isolated from Wounds of Burn Patients in Tripoli-Libya. J Microbiol Infect Dis. (2012), [cited February 03, 2024]; 2(3): 109-112 . doi:10.5799/jmid2012.03.0053


Harvard Style

Abdulazziz Zorgani, Omar Elahmer, Hisham Ziglam, Khalifa Sifaw Ghenghesh (2012) In-vitro Activity of Tigecycline against Methicillin-Resistant Staphylococcus aureus Isolated from Wounds of Burn Patients in Tripoli-Libya. J Microbiol Infect Dis, 2 (3), 109-112 . doi:10.5799/jmid2012.03.0053


Turabian Style

Abdulazziz Zorgani, Omar Elahmer, Hisham Ziglam, Khalifa Sifaw Ghenghesh. 2012. In-vitro Activity of Tigecycline against Methicillin-Resistant Staphylococcus aureus Isolated from Wounds of Burn Patients in Tripoli-Libya. Journal of Microbiology and Infectious Diseases, 2 (3), 109-112 . doi:10.5799/jmid2012.03.0053


Chicago Style

Abdulazziz Zorgani, Omar Elahmer, Hisham Ziglam, Khalifa Sifaw Ghenghesh. "In-vitro Activity of Tigecycline against Methicillin-Resistant Staphylococcus aureus Isolated from Wounds of Burn Patients in Tripoli-Libya." Journal of Microbiology and Infectious Diseases 2 (2012), 109-112 . doi:10.5799/jmid2012.03.0053


MLA (The Modern Language Association) Style

Abdulazziz Zorgani, Omar Elahmer, Hisham Ziglam, Khalifa Sifaw Ghenghesh. "In-vitro Activity of Tigecycline against Methicillin-Resistant Staphylococcus aureus Isolated from Wounds of Burn Patients in Tripoli-Libya." Journal of Microbiology and Infectious Diseases 2.3 (2012), 109-112 . Print. doi:10.5799/jmid2012.03.0053


APA (American Psychological Association) Style

Abdulazziz Zorgani, Omar Elahmer, Hisham Ziglam, Khalifa Sifaw Ghenghesh (2012) In-vitro Activity of Tigecycline against Methicillin-Resistant Staphylococcus aureus Isolated from Wounds of Burn Patients in Tripoli-Libya. Journal of Microbiology and Infectious Diseases, 2 (3), 109-112 . doi:10.5799/jmid2012.03.0053


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All correspondence should be addressed to:

Prof. Ibrahim Eldaghayes

Editor-in-Chief

Journal of Microbiology and Infectious Diseases

Department of Microbiology and Parasitology 

Faculty of Veterinary Medicine

University of Tripoli

P.O. Box 13662, Tripoli, Libya