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Research Article


A Retrospective Study on Presence of Herpesviruses in Suspected Herpes Encephalitis Patients in Sri Lanka

Hewa Babarandage Chathurika Harshani, Denagama Vitharanage Rishan Geeth Ruwan, Jinadari Maduwanthi Munasinghe, Gamage Don Diluk Chathuranga, Janaki I Abeynayake.

Abstract
Abstract:
Background: Encephalitis is a rare and serious brain infection that can be fatal. Viruses are common infectious agents causing encephalitis. Prompt detection of human herpes viruses in Cerebrospinal fluid (CSF) is crucial for early diagnosis and timely initiation of appropriate treatment, as this can significantly improve patient outcomes.
Aim: This study aimed to determine the presence of herpes simplex virus type 1, 2 (HSV-1, 2) and varicella–zoster virus (VZV) in cerebrospinal fluid samples (CSF) of suspected herpes encephalitis (HE) patients and to analyze demographic and associated clinical features.
Method: All CSF samples from HE suspected patients from different hospitals and/or facilities received at Medical Research Institute in Sri Lanka from January 2022 to January 2023 were included in this retrospective study. Real-time PCR was used to detect HSV1, 2 and VZV in the samples.
Results: From 1801 suspected herpes encephalitis cases (mean age 25.67; range 2 days to 88 years; male: female; 1003: 798), 18 (0.99%; male: female; 13: 5) were positive for herpes viruses; HSV-1(9, 0.50%), HSV-2 (5, 0.28%), HSV1 & 2 (1, 0.06%), and VZV (3, 0.17%). HSV-1 positivity: infants 0.54% (1/184), children 0.65% (4/618), adults 0.63% (4/627). HSV-2: children 0.16% (1/618), adults 0.48% (3/627), older adults 0.57% (1/175). VZV: adults 0.31% (2/627), older adults 0.57% (1/175). Prominent symptoms: fever and headache.

Key words: Cerebrospinal fluid, encephalitis, herpes simplex virus, PCR, varicella–zoster virus


 
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How to Cite this Article
Pubmed Style

Harshani HBC, Ruwan DVRG, Munasinghe JM, Chathuranga GDD, Abeynayake JI. A Retrospective Study on Presence of Herpesviruses in Suspected Herpes Encephalitis Patients in Sri Lanka. J Microbiol Infect Dis. 2023; 13(4): 190-195. doi:10.5455/JMID.2023.v13.i4.4


Web Style

Harshani HBC, Ruwan DVRG, Munasinghe JM, Chathuranga GDD, Abeynayake JI. A Retrospective Study on Presence of Herpesviruses in Suspected Herpes Encephalitis Patients in Sri Lanka. https://www.jmidonline.org/?mno=170598 [Access: February 02, 2024]. doi:10.5455/JMID.2023.v13.i4.4


AMA (American Medical Association) Style

Harshani HBC, Ruwan DVRG, Munasinghe JM, Chathuranga GDD, Abeynayake JI. A Retrospective Study on Presence of Herpesviruses in Suspected Herpes Encephalitis Patients in Sri Lanka. J Microbiol Infect Dis. 2023; 13(4): 190-195. doi:10.5455/JMID.2023.v13.i4.4



Vancouver/ICMJE Style

Harshani HBC, Ruwan DVRG, Munasinghe JM, Chathuranga GDD, Abeynayake JI. A Retrospective Study on Presence of Herpesviruses in Suspected Herpes Encephalitis Patients in Sri Lanka. J Microbiol Infect Dis. (2023), [cited February 02, 2024]; 13(4): 190-195. doi:10.5455/JMID.2023.v13.i4.4



Harvard Style

Harshani, H. B. C., Ruwan, . D. V. R. G., Munasinghe, . J. M., Chathuranga, . G. D. D. & Abeynayake, . J. I. (2023) A Retrospective Study on Presence of Herpesviruses in Suspected Herpes Encephalitis Patients in Sri Lanka. J Microbiol Infect Dis, 13 (4), 190-195. doi:10.5455/JMID.2023.v13.i4.4



Turabian Style

Harshani, Hewa Babarandage Chathurika, Denagama Vitharanage Rishan Geeth Ruwan, Jinadari Maduwanthi Munasinghe, Gamage Don Diluk Chathuranga, and Janaki I Abeynayake. 2023. A Retrospective Study on Presence of Herpesviruses in Suspected Herpes Encephalitis Patients in Sri Lanka. Journal of Microbiology and Infectious Diseases, 13 (4), 190-195. doi:10.5455/JMID.2023.v13.i4.4



Chicago Style

Harshani, Hewa Babarandage Chathurika, Denagama Vitharanage Rishan Geeth Ruwan, Jinadari Maduwanthi Munasinghe, Gamage Don Diluk Chathuranga, and Janaki I Abeynayake. "A Retrospective Study on Presence of Herpesviruses in Suspected Herpes Encephalitis Patients in Sri Lanka." Journal of Microbiology and Infectious Diseases 13 (2023), 190-195. doi:10.5455/JMID.2023.v13.i4.4



MLA (The Modern Language Association) Style

Harshani, Hewa Babarandage Chathurika, Denagama Vitharanage Rishan Geeth Ruwan, Jinadari Maduwanthi Munasinghe, Gamage Don Diluk Chathuranga, and Janaki I Abeynayake. "A Retrospective Study on Presence of Herpesviruses in Suspected Herpes Encephalitis Patients in Sri Lanka." Journal of Microbiology and Infectious Diseases 13.4 (2023), 190-195. Print. doi:10.5455/JMID.2023.v13.i4.4



APA (American Psychological Association) Style

Harshani, H. B. C., Ruwan, . D. V. R. G., Munasinghe, . J. M., Chathuranga, . G. D. D. & Abeynayake, . J. I. (2023) A Retrospective Study on Presence of Herpesviruses in Suspected Herpes Encephalitis Patients in Sri Lanka. Journal of Microbiology and Infectious Diseases, 13 (4), 190-195. doi:10.5455/JMID.2023.v13.i4.4