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Abstract - A Case of Meropenem Induced Cholestasis
Büşra Canbaz, Özgür Kara, Güneş Arık, Gözde Şengül Ayçiçek, Fatih Sümer, Zekeriya Ülger

A Case of Meropenem Induced Cholestasis

Busra Canbaz, Ozgur Kara, Gunes Arık, Gözde Sengul Aycicek, Fatih Sumer, Zekeriya Ulger

Department of Geriatrics, Gazi University, Ankara, Turkey

ABSTRACT

Meropenem is a broad-spectrum carbapenem antibiotic used for complicated hospital infections. Mild aminotransferase elevations have been reported in meropenem recipients, but cholestasis is rare. A 70 year old man was admitted for infected diabetic foot ulcer.  ALP and GGT levels started increasing one week after the initiation of meropenem, with normal ALT, AST and bilirubin levels. Meropenem induced intrahepatic cholestasis was suspected and meropenem was discontinued, followed by normalization of liver enzymes.

Drug induced liver injury should be suspected in patients with unexplained liver enzyme elevations. J Microbiol Infect Dis 2016;6(4): 190-191

Keywords: Meropenem; drug induced liver injury; cholestasis

Volume 06, Number 04 (2016)