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Abstract - Drug interaction of bocepravir and amlodipine in a patient with hepatitis C: A Cardiovascular follow-up
Çiğdem Kader, Hüseyin Ede, Ayşe Erbay, Alirıza Erbay

Drug interaction of boceprevir and amlodipine in a patient with hepatitis C: A cardiovascular follow-up

Çiğdem Kader, Hüseyin Ede, Ayşe Erbay, Ali Rıza Erbay

 Bozok University, School of Medicine Department of Infectious Diseases and Clinical Microbiology, Yozgat, Turkey

 

ABSTRACT
Boceprevir is a NS3/4A hepatitis C virus (HCV) protease inhibitor, used in combination with peginterferon and ribavirin to treat HCV. Boceprevir undergoes extensive metabolism via cytochrome P450-mediated oxidation and ketoreduction by cytosolic aldo-keto reductases. Amlodipine has been used for the treatment of patients with hypertension and also metabolised through cytochrome P450 pathway. Here, we presented a case of boceprevir and amlodipine interaction in a patient with chronic HCV and her echocardiography and electrocardiographic follow-up results. J Microbiol Infect Dis 2015;5(1): 32-35
Key words: Amlodipine, boceprevir, drug ınteraction

 

Çiğdem Kader, Hüseyin Ede, Ayşe Erbay, Ali Rıza Erbay Drug interaction of boceprevir and amlodipine in a patient with hepatitis C: A cardiovascular follow-up

J Microbiol Infect Dis 2015; 5(1): 32-35 doi: 10.5799/ahinjs.02.2015.01.0172

Volume 05, Number 01 (2015)

Volume 05, Number 01 (2015)