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Abstract - In vitro efficacy of fosfomycin against clinical strains
Adil Karadag, Yeliz Tanriverdi Caycı, Kemal Bilgin, Murat Gunaydin, Cafer Eroglu

In vitro efficacy of fosfomycin against clinical strains
Adil Karadağ, Yeliz Tanrıverdi Çaycı, Kemal Bilgin, Murat Günaydın, Cafer Eroğlu
ABSTRACT
Objectives: Fosfomycin is an alternative drug for treatment of uncomplicated urinary tract infections. This study aimed to investigate in vitro activity of fosfomycin against methicillin-resistant Staphylococcus aureus (MRSA), methicillin-resistant coagulase negative staphylococci (MRCoNS), vancomycin-resistant Enterococcus faecium (VR E. faecium), Escherichia coli, Klebsiella pneumoniae, and Enterobacter isolates.
Methods: Clinical isolates of MRSA, MRCoNS, E. coli, K. pneumoniae and Enterobacter spp. and VRE isolates which were isolated from rectal swaps were identified with Vitek 2 Compact (Biomeriux, France) and BD Phoenix (BD USA) automated systems. The Kirby-Bauer disc diffusion method was used to determine the susceptibility to fosfomycin.
Results: All the MRSA (n=40), MRCoNS (n=40), and VR E. faecium (n=62) isolates were susceptible to fosfomycin. The fosfomycin susceptibility rates for E. coli, K. pneumoniae, and Enterobacter spp. were 97.5% (39 of 40), 97.3% (36 of 37), and 86.9% (20 of 23), respectively. One (2.7%) isolate of K. pneumoniae and three (13.1%) isolates of Enterobacter spp. showed intermediate susceptibility to fosfomycin. Resistance to fosfomycin was detected in only one (2.5%) isolate of E. coli.
Conclusion: Based on the results of our study, fosfomycin is highly active against a collection of several gram-positive and gram-negative bacteria, including multidrug resistant isolates, and is an alternative drug in the treatment option. J Microbiol Infect Dis 2014;4(2): 55-58 doi: 10.5799/ahinjs.02.2014.02.0127
Key words: Fosfomycin, gram-positive bacteria, gram-negative bacteria, antimicrobial agent

Volume 04, Number 02 (2014)