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Abstract - Persistent Colonization of Helicobacter pylori in Human Gut induces gastroduodenal diseases.
Animesh Sarker

Persistent colonization of Helicobacter pylori in human gut induces gastroduodenal diseases

Animesh Sarker, Tasnim Ahmed, Marufa Nasreen, Rafiad Islam, Rezual Islam, Noor Jahan

Department of Biotechnology and Genetic Engineering, University of Mawlana Bhashani Science and Technology.Santosh,Tangail-1902.Bangladesh

ABSTRACT

Helicobacter pylori are gut bacteria colonize in the epithelial cell lining of the stomach and persist there for long du­ration. Around two-thirds of the world’s populations are infected with H. pylori and cause more than 90 percent of ulcers. The development of persistent inflammation is the main cause of chronic gastritis that finally results in a severe consequence known as stomach cancer. Two major virulence factors cytotoxin-associated gene product (cagA) and the vacuolating toxin (vacA) are mostly investigated as their close association with gastric carcinoma. In this review, host im­munity against H. pylori infection and their evasion mechanism are intensely explored. It is the fact, that understanding pin point molecular mechanisms of any infection is critical to develop novel strategies to prevent pertinent diseases. .J Microbiol Infect Dis 2014; 4(4): 170-176

Key words: vacA, cagA, miRNA, COX-2, Gastric carcinoma ver.

Animesh Sarker, Tasnim Ahmed, Marufa Nasreen, Rafiad Islam, Rezual Islam, Noor Jahan. Persistent colonization of Helicobacter pylori in human gut induces gastroduodenal diseasesJ Microbiol Infect Dis 2014; 4(4): 170-176 doi: 10.5799/ahinjs.02.2014.04.0164

 

Volume 04, Number 04 (2014)