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Abstract - Two Cases of Hantavirus Infection in Crimean-Congo Haemorrhagic Fever Endemic Region
Mustafa Sunbul, Hava Yılmaz, Hasan Çetinkaya, Yavuz Uyar, Dilek Çaglayık, Fatih Bostancı, Hakan Leblebicioglu


Crimean-Congo Hemorrhagic Fever (CCHF) and Leptospirosis are endemic in our region. Hantavirus infections may be 
confused with similar clinical picture zoonotic infections. Two patients with fever, malaise, cough, phlegm, nausea, vom-
iting, thrombocytopenia, renal failure, elevated transaminases, and a history of mouse contact were hospitalized in our 
clinic with a presumptive diagnosis of  leptospirosis, pneumonia, CCHF and Hantavirus  infections. Empirical antibiotic 
treatment was  initiated and CCHF and  leptospirosis was ruled out with  laboratory  tests. Hantavirus  immunoglobulin 
(Ig)-G and  Ig-M antibodies were detected positive by  immunoluorescent antibody  (IFA) method  in both cases but, 
Dobrova virus was detected  in only one patient with  immunoblotting methods. Both patients were discharged after 
treatment. Hantavirus infections may be misdiagnosed as zoonotic infections since they have similar clinical picture. It 
should be considered in the differential diagnosis of patients with a history of contact with mouse. J Microbiol Infect Dis 
2012; 2(3): 117-120
Volume 02, Number 03 (2012)