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Journal of Clinical and Experimental Investigations is licenced under the terms of Creative Commons Attribution-Non Commercial4.0 International (CC BY-NC 4.0) License.
Abstract - Risk factors for nosocomial pneumonia in intensive care units of a University Hospital
Yasemin Akkoyunlu, Nefise Öztoprak, Hande Aydemir, Nihal Pişkin, Güven Çelebi, Handan Ankaralı, Deniz Akduman

Objective: The evaluation of risk factors in patients with Nosocomial pneumonia (NP) may provide useful guidance for patients who need intensive care. The aim of this study was to identify risk factors of NP in ICU.

Methods: During the six months period of time, patients who stayed in ICUs for at least 48 hours were included in a tertiary medical center. A total of 304 patients were prospectively followed and 78 of them who developed NP made up the NP group. Patients who did not develop any infection were defined as control group. Variables which was thought or detected as a risk factor of NP in univariate analysis were analyzed with multivariate logistic regression analysis.

Results: Among 304 patients, 78 (25.6%) had NP. Multivariate analysis revealed that advanced age (odds ratio [OR] 1, 95% confidence interval [CI] 1.00-1.06), length of stay (LOS) in the ICU (OR 1.3, 95% CI 1.17-1.39), prior infection on admission to ICU (OR 6.7, 95% CI 1.52-29.94), transfusion of blood and blood products (OR 4.0, 95% CI 1.43-11.46) and prior antibiotic usage within the last two weeks before admission (OR 3.3, 95% CI 1.28-8.48) were independent risk factors for NP. Additionally, the mean APACHE II score of cases with NP (16.7±6.7) was significantly higher than that of controls (11.5±8.1; p<0.001).

Conclusion: We must be awake to make the diagnosis earlier in patients with determined risk factors: advanced age, LOS in ICU, prior infection, transfusion of blood products and prior antibiotic usage. 

Volume 03, Number 01 (2013)