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Abstract - BK Virus Pneumonia with CMV Colitis in a Kidney Transplant Recipient: First Successful Treatment with Non-Cidofovir Based Therapy
Ali Chaito, Mouhamad Nasser, Hussein Karnib, Amal Hamieh

BK Virus Pneumonia with CMV Colitis in a Kidney Transplant Recipient: Successful Treatment with Non-Cidofovir Based Therapy

 

Ali R. Chaitou1, Mouhamad Nasser2, Hussein Karnib3, Amal Hamieh4

1Department of Internal Medicine, Faculty of Medical Sciences, Lebanese University, Hadat, Lebanon

2Department of Respiratory Medicine, National Reference Center for Rare Pulmonary Diseases, Louis Pradel Hospital, Hospices Civils de Lyon Claude Bernard University Lyon 1, Lyon, France

3Department of internal Medicine, Division of Nephrology, Al Rassoul Al-Aazam University Hospital, Beirut, Lebanon

4Department of Internal Medicine, Division of Infectious Diseases, Al Rassoul Al-Aazam University Hospital, Beirut, Lebanon

 

ABSTRACT

BK virus (BKV) pneumonia is a rare entity especially seen in immunosuppressed patients, for which cidofovir is the used treatment option. We describe a case of a young female patient who presented for altered kidney function six months following kidney transplantation for focal segmental glomerulosclerosis and was found to have BKV nephritis.  Her in-hospital stay was complicated by BKV pneumonia requiring mechanical ventilation, in addition to CMV colitis. She was treated with leflunomide/ciprofloxacin and ganciclovir for her pneumonia and colitis, respectively. The patient improved clinically except that her kidney function deteriorated. Leflunomide/ciprofloxacin combination may constitute an effective and safe alternative to cidofovir for the treatment of BKV pneumonia, in particular when cidofovir is not available. J Microbiol Infect Dis 2021; 11(1):36-41.

Keywords: BK virus pneumonia; CMV colitis; Kidney transplantation; Leflunomide; Ciprofloxacin

Volume 11, Number 01 (2021)