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Abstract - Trichosporon Asahii Infection Mortality in Pediatric Oncology Patients. A Report of Six Cases.
Adil Abdelhamed Abbas, Abdulfattah Wasel Alamri, Areej Hasan Almofti

Trichosporon Asahii Infection Mortality in Pediatric Oncology Patients: A Report of Six Cases

 

Adil Abdelhamed Abbas1, Abdulfattah Wasel Alamri2, Areej Hassan Almofti2

1College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Pediatric Hematology/Oncology Section, Princess Nourah Oncology Centre, King Abdulaziz Medical City, Jeddah, Saudi Arabia

2College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Department of Laboratory Medicine, King Abdulaziz Medical City, Jeddah, Saudi Arabia

 

ABSTRACT

The frequency of invasive fungal infections in patients with hematological malignancies has dramatically increased over the last two decades mainly due to increased use of more intensive therapies. Trichosporon spp is an uncommon but frequently fatal invasive yeast infection that occur predominantly in patients with hematological malignancies. Trichosporon Asahii (T. Asahii) is the most common genus isolated and is reported to cause serious invasive infections in adults and infrequently in children. Voriconazole (VCZ) remains the antifungal drug of choice. We report six pediatric patients with acute lymphoblastic leukemia (2), acute myeloblastic leukemia (2), lymphoblastic lymphoma (1) who developed invasive T. Asahii infection during the early phases of CTR. The outcome was poor. Five patients have died as a result of the infection after a stormy clinical course and prolonged stay in the pediatric intensive care unit despite receiving proper antifungal treatment. Only one patient survived the infection without serious sequalae. J Microbiol Infect Dis 2020; 8(3):167-172.

Keywords: Amphotericin B, Caspofungin, Invasive fungal infections, Trichosporon Asahii, Voriconazole

Volume 10, Number 03 (2020)