DRESS Syndrome- Uncommon Drug Reaction with Common Disease Treatment: A Case Report

B Saroj Kumar Prusty¹, Yugvaveer K Goud², Kiran Kumar Ramineni³, Safina Perveen¹, Majed Abdulbasit Momin⁴

¹Yashoda Hospitals, Malakpet Branch Hyderabad , Department of Critical Medicine, Hyderabad, India

²Yashoda Hospitals, Malakpet Branch Hyderabad, Department of Pulmonology, Hyderabad, India

³Yashoda Hospitals, Malakpet Branch Hyderabad, Department of Neurology, Hyderabad, India

⁴Yashoda Hospitals, Malakpet Branch Hyderabad, Department of Laboratory Medicine, Hyderabad, India

ABSTRACT

Drug Reaction with Eosinophilia and Systemic symptoms (DRESS syndrome), is a severe adverse reaction associated with diverse collection of drugs, characterized by severe mucocutaneous rash, eosinophilia, fever, lymphadenopathy and extensive systemic involvement. We report a case of a 21-year-old female who developed clinical manifestations of fever, maculopapular rash, lymphadenopathy, eosinophilia and systemic symptoms after taking antitubercular medication for pulmonary tuberculosis, with subsequent development of acute liver failure with encephalopathy and coagulopathy. She was managed successfully with withdrawal of the offending medication and supportive care in intensive care unit. This case highlights the importance of consideration of antitubercular medication related drug reaction even with delayed onset of symptoms. J Microbiol Infect Dis 2020; 10(4): 225-229.

Keywords: Anti-tubercular treatment, DRESS syndrome, Eosinophilia, Management