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Abstract - Epidemiology of Candida colonization and infection in medical surgical intensive care unit of a tertiary care hospital
Afzal Azim, Armin Ahmed, Arvind Kumar Baronia, Reema Yadav, Preeti Sharma, Rungmei SK Marak

Epidemiology of Candida colonization in medical surgical intensive care unit of a tertiary care teaching hospital of North India

Afzal Azim1, Armin Ahmed2, Arvind Kumar Baronia1, Reema Yadav3, Preeti Sharma3, Rungmei S. K. Marak3

1Department of Critical Care Medicine, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India

2Department of Critical Care Medicine, King George’s Medical University, Lucknow, India

3Department of Microbiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India

 

ABSTRACT

Objective: Invasive candidiasis is associated with increased morbidity and mortality in critically ill patients. Current study was undertaken to study the colonization trend in critically ill patients admitted to a medical /surgical ICU of a tertiary care teaching hospital.

Methodology: Data for the current study has been derived from a larger database generated for external validation of risk prediction scores for invasive candidiasis conducted in a 12 bedded medical/surgical ICU of a tertiary care hospital of North India. Non neutropenic adult patients with >48 hours of ICU stay were included in the study. Colonization surveillance samples were collected from oral cavity, endotracheal aspirates, axilla, perineum and urine at the time of admission and then on 3rd, 7th, 14th and 21st day of ICU stay. Blood culture samples were taken at admission and then as per physician’s discretion.

Results: Total 200 patients were enrolled from July 2013 to November 2014. Ninety five percent patients were colonized with Candida either at admission or during their stay in ICU. The most common species responsible for colonization was Candida glabrata (27%) followed by C. tropicalis (20.5%) and C. auris (18%). Seventeen patients developed Candida blood stream infection. C. tropicalis was the most common species causing candidemia. C.auris was most frequent colonizer of axilla (54.2%), while rectal swabs had high growth of C. glabrata (44.9%).

Conclusion: Our study population had high rate of Candida colonization. C. glabrata was the most common colonizer followed by C. tropicalis.  J Microbiol Infect Dis 2018; 8(4):147-152.

Keywords: Candida auri, Candida colonization, Candida glabrata, Candida tropicalis; critically ill  

Volume 08, Number 04 (2018)