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Abstract - Profile of Person Affected by Leprosy with Clinical Relapse among in High Endemic State of India
Sunil Vilasrao Gitte, Chaitanya Nigam, Ashish Birendra Chakraborty, Krishnamurty Kamble, Mukesh Kumar Soni, Rupam Gahlot

Profile of Person Affected by Leprosy with Clinical Relapse among in High Endemic State of India

Sunil Vilasrao Gitte1, Chaitanya Nigam1, Ashish B Chakraborty1, Krishnamurty Kamble1, Mukesh Soni1, Rupam Gahlot2

1Regional Leprosy Training and Research Institute, Lalpur, Raipur, Chhattisgarh, India

2Department of Microbiology, Government Medical College, Rajnandgaon, Chhattisgarh, India

ABSTRACT

Objective: Relapse is not an unusual phenomenon in leprosy, there are many predisposing factors which may lead to occurrence of relapse; some of these include the presence of persistent bacilli, drug monotherapy, inadequate or irregular therapy. Patients usually presents with presence of multiple skin lesions and/or thickened nerves, reason for early relapse is probably bacillary persistence due to inadequate treatment and for late relapse due to or re-infection. The objectives of this study are to assess various clinico-epidemiological factors associated with the occurrence of relapses in leprosy patients.

Methods: A hospital record based retrospective follow-up study has been performed and 117 relapse cases of leprosy were included. Leprosy relapse cases presented in the study hospital were interviewed using a predesigned and pretested preformed. Each patient was subjected to clinical, bacteriological and disability assessments for diagnosis of relapse and followed until the completion of multi drug therapy.

Results: During a study period, relapse was seen more in male as compared to female. The duration between cessation of the treatment and re-appearance of new lesions varied from 1 to 33 years. Disability proportion was high among MB patients.

Conclusion: Relapse in leprosy should be thoroughly examined and looked for drug resistance. J Microbiol Infect Dis 2018; 8(3):103-107

Keywords: Drug resistance, Disability, Leprosy, MDT, Multibacillary, Paucibacillary, Relapse

 

Volume 08, Number 03 (2018)