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Abstract - Apophysomyces elegans caused Rhino-Orbito Mucormycosis: An emerging infection in immunocompetent individuals
Dhaneshwor Naorem Singh, Nishi Sharma, Lobzang Dawa, shalini malhotra

Apophysomyces elegans Caused Rhino-Orbito Mucormycosis: An Emerging Infection in Immunocompetent Individuals

N. Dhaneshwor Singh1, Nishi Sharma1, Lobzang Dawa1, Shalini Malhotra2

1Department of ENT, Dr. Ram Manohar Lohia Hospital & PGIMER, New Delhi, India

4Department of Microbiology, Dr. Ram Manohar Lohia Hospital &PGIMER, New Delhi, India

 

ABSTRACT

Mucormycosis is a rare necrotizing angioinvasive infection caused by fungi of the class Zygomycetes (order Mucorales). It predominantly occurs in immunocompromised/ predisposed individuals. Recent surge in its incidence in healthy individuals has emphasized the need to reconsider our age-old presumption of 'mucormycosis as a classical opportunistic infection'. Apophysomyces elegans has emerged as a pathogen causing invasive Rhino-Orbitocerebral Mucormycosis (ROCM), mostly in immunocompetent individuals. Mostly resistant to commonly used azoles and echinocandins, management of A elegans associated ROCM solely depends on radical debridement and Amphotericin B. Recent reports of Amphotericin B resistant A elegans strains is disturbing. Till date only 12 cases of ROCM in immunocompetent/ otherwise healthy individuals attributable to A elegans has been reported.

Our main objective is to delineate the clinical characteristics and treatment outcome of immunocompentent/ otherwise healthy individuals suffering from A elegans caused ROCM. We also report four new cases of A. elagans caused ROCM. J Microbiol Infect Dis 2017; 7(4):207-212

Keywords: Mucormycosis, Apophysomyces elegans, Rhino-Orbitocerebral Mucormycosis, Immunocompetent

Volume 07, Number 04 (2017)