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Abstract - Comparative antimicrobial efficacy of silymarin and silibinin against oral microbes
Radhika Murali Iyangar, Ezhilarasan Devaraj, Gopinath Prakasm

Antimicrobial Efficacy of Silymarin and Silibinin Against Oral Microorganisms

Murali Iyangar Radhika1, Devaraj Ezhilarasan1, Prakasam Gopinath2

1Radhika MI, Ezhilarasan D, Department of Pharmacology, Saveetha Dental College and Hospitals, Saveetha University, Chennai, Tamil Nadu, India

2Gopinath P, Department of Microbiology, Saveetha Dental College and Hospitals, Saveetha University, Chennai, Tamil Nadu, India



Objective: To evaluate the antimicrobial effect of silymarin and silibinin, a plant derived flavonoid compounds against oral microorganisms that are responsible for dental caries.

Methods: In the current investigation, we analyzed the comparative antibacterial and antifungal effect of silibinin and silymarin against clinical cariogenic oral pathogens through evaluating their minimum inhibitory and minimum bactericidal concentration. We used clinical isolates that are responsible for dental caries and these include Candida albicans, Enterococcus faecalis, Lactobacillus acidophilus, Staphylococcus aureus and Streptococcus mutans to evaluate the anticariogenic potential of silymarin and silibinin.

Results: In the present investigation, silymarin exhibit good antimicrobial effect against most of the oral cariogenic microorganisms tested when compared to silibinin. Interestingly, silymarin shows high sensitivity at a concentration of <5 µg/ml against S. mutans, L. acidophilus and C. albicans. On the other hand, silibinin also have significant antimicrobial effect against the oral pathogens. 

Conclusions: Silymarin and silibinin can be used as appropriate drug candidates that control dental caries, endodontic infections. J Microbiol Infect Dis 2017; 7(3):139-143

Keywords: silibinin, silymarin, oral infections, oral pathogens

Volume 07, Number 03 (2017)