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Abstract - Antimicrobial susceptibility pattern in children with typhoid fever and serotype of Salmonella typhi in Jakarta
Mirari Prasadajudio, Mulya Rahma Karyanti, Lia Waslia, Decy Subekti, Bambang Supriyatno, John Kevin Baird

Antimicrobial Susceptibility among circulating Salmonella typhi serotypes in Children in Jakarta, Indonesia

Mirari Prasada Judio, Mulya Karyanti, Lia Waslia, Decy Subekti, Bambang Supriyatno, Kevin Baird

 

ABSTRACT

Objectives: Indonesia is known for high incidence of typhoid fever especially in children. This study aimed to observe antibiotic susceptibility in circulating Salmonella typhi serotypes in children with typhoid.

Methods: A cross sectional study design was conducted. A total of 142 blood samples from children between 1 and 18 years old clinically diagnosed with suspected typhoid fever were recruited between January 2012 and July 2013 from six health centers in Jakarta. Confirmed cases were retrieved based on S. typhi isolate finding in blood culture. Antimicrobial susceptibility was investigated and PCR was used to detect S. typhi serotypes using fliB, fliC and aroC genes.

Results: The prevalence of confirmed typhoid case based on isolate finding was 22 (15.5%). Twenty of S. typhi isolates expressed fliC gene carrying H:d allele, the other two expressed j allele, while only two samples expressed fliB, all showed no difference in pathogenicity and antimicrobial resistance.

Conclusions: Circulating serotypes found in typhoid children in Jakarta, Indonesia are still susceptible even to the firstline antimicrobials. Thus, chloramphenicol, ampicillin and co-trimoxazole are still recommended. J Microbiol Infect Dis 2017; 7(1): 29-35

Keywords: Salmonella typhi, child, serogroup, microbial sensitivity test

Volume 07, Number 01 (2017)