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Abstract - Factors Associated with Treatment Failure among Smear Positive TB Patients in Khorasan-e-Razavi and Sistan-Baluchistan Provinces, Iran
Hekmatollah Khoubfekr, Narges Khanjani, Yunes Jahani, Mahmoud Moosazadeh

Factors Associated with Treatment Failure among Smear Positive TB Patients in Khorasan-e-Razavi and Sistan-Baluchistan Provinces, Iran

Hekmatollah Khoubfekr1, Narges Khanjani2, Yunes Jahani3, Mahmoud Moosazadeh4

1 Department of Epidemiology, School of Public Health, Kerman University of Medical Sciences, Kerman, Iran.

2 Department of Epidemiology, School of Public Health, Kerman University of Medical Sciences, Kerman, Iran.

3 Social Determinants of Health Research Center, Institute of Futures Studies in Health, Department of Biostatistics and Epidemiology, School of Public Health, Kerman University of Medical Sciences, Kerman, Iran.

4 Assistant Professor, Health Sciences Research Center, School of Public Health, Mazandaran University of Medical Sciences, Sari, Iran

ABSTRACT

Introduction: Tuberculosis (TB) treatment failure is one of the major problems of the health sector in developing countries. Poor treatment of patients leads to drug resistance, relapse, death, and ultimately prevents TB control programs. This study was conducted to determine the factors affecting tuberculosis treatment failure in Khorasan and Sistan- Balochistan regions which have a high prevalence of TB.

Methods: In this case - control study 270 patients with tuberculosis (90 cases, 180 controls) were analyzed. New TB patients registered with failure to treatment according to the national protocol between March 2008 - March 2012 were chosen as cases and new TB patients with negative sputum smear in the same time frame were enrolled as control group. Demographic data and clinical treatment outcomes were collected through interviews and file records. Multivariate logistic regression analysis was used to determine the predictors of treatment failure in SPSS 19.

Results: Independent factors and predictors of failure treatment included illiteracy, a three plus positive sputum smear, positive sputum smear at end of the second month, non-implementation of the Directly Observed Treatment Short strategy by healthcare staff, history of addiction and history of diabetes.

Conclusion: Intervention programs for early detection and control of diabetes, drug control programs, giving priority to providing DOTS by health care workers, more individual care and attention to patients with initial smear p + 3 or those that remain sputum positive at the end of the end of the second month or those who are less educated is necessary. J Microbiol Infect Dis 2016;6(4): 172-178

Key words: Tuberculosis, Treatment failure, Iran.

Volume 06, Number 04 (2016)